ArticleMolecular systems biology2019
p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions.
Article in Molecular systems biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Transient peak of p53 induction persists at low radiation doses in MCF-7 cells.Molecular biology reports · 2026Article
- Review
- Epigenome regulators imbue a single eukaryotic promoter with diverse gene expression dynamics.iScience · 2026Article
- SPIFEE -- A pipeline for analyzing traces of live-cell fluorescence microscopy data.bioRxiv : the preprint server for biology · 2026Article
- Genetic resonance in the p53 signaling network.Cell systems · 2026Article
- Decoding the Central Dogma: Quantitative Insights into Transcription and Translation Dynamics in the p53-Mediated DNA Damage Response.Journal of molecular biology · 2026Review
- Design principles of gene circuits for longevity.Trends in cell biology · 2025Review
- The advantage of periodic over constant signalling in microRNA-mediated regulation.Nucleic acids research · 2025Article
- Frequency-Dependent Premature Differentiation of Pheochromocytoma Cells Exhibits Band-Pass Filter Behavior Correlation with Intracellular Enzyme Activation Kinetics.International journal of molecular sciences · 2025Article
- Entrainment and multi-stability of the p53 oscillator in human cells.Cell systems · 2024Article
- Determinants of p53 DNA binding, gene regulation, and cell fate decisions.Cell death and differentiation · 2024Review
- Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach.The Journal of pharmacology and experimental therapeutics · 2024Article
- Review
- A guide to ERK dynamics, part 2: downstream decoding.The Biochemical journal · 2023Article
- Review
- Degradation-driven protein level oscillation in the yeast Saccharomyces cerevisiae.Bio Systems · 2022Article
- Reading oscillatory instructions: How cells achieve time-dependent responses to oscillating transcription factors.Current opinion in cell biology · 2022Review
- Principles, mechanisms and functions of entrainment in biological oscillators.Interface focus · 2022Review
- Time-series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations.Molecular systems biology · 2022Article
- Mapping the dynamic transfer functions of eukaryotic gene regulation.Cell systems · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The p53 tumor suppressor regulates distinct responses to cellular stresses. Although different stresses generate different p53 dynamics, the mechanisms by which cells decode p53 dynamics to differentially regulate target genes are not well understood. Here, we determined in individual cells how canonical p53 target gene promoters vary in responsiveness to features of p53 dynamics. Employing a chemical perturbation approach, we independently modulated p53 pulse amplitude, duration, or frequency, and we then monitored p53 levels and target promoter activation in individual cells. We identified distinct signal processing features-thresholding in response to amplitude modulation, a refractory period in response to duration modulation, and dynamic filtering in response to frequency modulation. We then showed that the signal processing features not only affect p53 target promoter activation, they also affect p53 regulation and downstream cellular functions. Our study shows how different promoters can differentially decode features of p53 dynamics to generate distinct responses, providing insight into how perturbing p53 dynamics can be used to generate distinct cell fates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.