ArticlePediatric blood & cancer2020
Barriers and facilitators of clinical trial enrollment in a network of community-based pediatric oncology clinics.
Article in Pediatric blood & cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Twenty-year trends in racial and ethnic enrollment in large diabetes randomized controlled trials.BMC medicine · 2022Pooled it
- Journal of child health care : for professionals working with children in the hospital and community · 2022Trial
- Evaluation of an Interactive, Educational Website Developed for Adolescents to Learn About Pediatric Clinical Trials: DigiKnowIt News.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersTrial
- Disparities in Rural-Urban Cancer Care Outcomes among Pediatric, Adolescent, and Young Adult Populations: A Comprehensive Narrative Review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Review
- Pediatric Oncology Clinical Trial Participation Among Families From Historically Marginalized Groups.JAMA network open · 2026Article
- Identifying caregiver-reported modifiable barriers to pediatric oncology clinical trial enrollment and participation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Management of fatigue in children with cancer: a survey of pediatric hematology-oncology professionals' knowledge, attitudes, and practices in the United States and Canada.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Medulloblastoma in Adolescents and Young Adults (AYA): Bridging Pediatric Paradigms and Adult Oncology Practice.Journal of clinical medicine · 2025Review
- Multilevel challenges to equitable inclusion of children in trials when parents use languages other than English: A qualitative report from Children's Oncology Group's Diversity and Health Disparities Committee Language Equity Working Group.Pediatric blood & cancer · 2024Article
- Perspectives of pediatric oncologists on referral for CAR-T therapy: a mixed methods pilot study.JNCI cancer spectrum · 2024Article
- Clinical trial recruitment of people who speak languages other than English: a Children's Oncology Group report.JNCI cancer spectrum · 2024Article
- Population-Based Data Linkage Describing Patterns of Cancer Clinical Trial Enrollment Among Children and Adolescents.JCO oncology practice · 2024Article
- Barriers to Clinical Trial Implementation Among Community Care Centers.JAMA network open · 2024Article
- Equitable communication for pediatric cancer patients and families who speak languages other than English.Pediatric blood & cancer · 2024Article
- Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population.JACC. CardioOncology · 2023Article
- Article
- Access to Chimeric Antigen Receptor T Cell Clinical Trials in Underrepresented Populations: A Multicenter Cohort Study of Pediatric and Young Adult Acute Lymphobastic Leukemia Patients.Transplantation and cellular therapy · 2023Article
- Barriers to Screening: An Analysis of Factors Impacting Screening for Type 1 Diabetes Prevention Trials.Journal of the Endocrine Society · 2023Article
- Barriers and facilitators to recruitment of underrepresented research participants: Perspectives of clinical research coordinators.Journal of clinical and translational science · 2023Article
- Extracting patient-level data from the electronic health record: Expanding opportunities for health system research.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
introductionMajor advances in the field of pediatric oncology have resulted from rigorous, prospective clinical oncology research trials. Optimizing access for all children and adolescents to clinical research trials is an important goal. Barriers to clinical trial enrollment are numerous, involving the health care system, research infrastructure, access to care, providers, and participants. The perspectives of pediatric oncologists may provide insight into the barriers of clinical trial enrollment for this unique population. METHODS AND MATERIALS: We conducted qualitative structured interviews over two months of pediatric oncologists in a community-based clinical network as part of a quality improvement project aimed at increasing enrollment rates at St. Jude Affiliate Clinics. We assessed barriers and facilitators to clinical trial opportunities for racial and ethnic minority pediatric participants. In the same fiscal year of the interviews, we tracked clinical trial enrollment by race and ethnicity of the participant over 12 months.
resultsThe major barriers to clinical trial enrollment for pediatric cancer minority participants included language discordance, travel difficulties, and complex trial designs. In contrast, the major facilitators included building trust with participants and their parents, and education on the merits of clinical research studies. We did not observe any disparities in clinical trial enrollment among the racial and ethnic minority participants of the clinical trials conducted across our network of pediatric oncology clinics.
conclusionsIdentifying barriers and facilitators may improve clinical trial enrollment for underrepresented participant groups.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.