Evidence map›Paper›PMID 31556245›Full record

ArticleCNS neuroscience & therapeutics2019

Minocycline reduces intracerebral hemorrhage-induced white matter injury in piglets.

Heng Yang, Xin-Jie Gao, Yan-Jiang Li, Jia-Bin Su, Tong-Zhou E, Xin Zhang, Wei Ni, Yu-Xiang Gu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Heng YangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Xin-Jie GaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yan-Jiang LiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Jia-Bin SuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Tong-Zhou EDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Xin ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Wei NiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yu-Xiang GuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-4580-2205
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWhite matter (WM) injury after intracerebral hemorrhage (ICH) results in poor or even fatal outcomes. As an anti-inflammatory drug, minocycline has been considered a promising choice to treat brain injury after ICH. However, whether minocycline can reduce WM injury after ICH is still controversial. In the present study, we investigate the effect and underlying mechanism of minocycline on WM injury after ICH.

methodsAn ICH model was induced by an injection of autologous blood into the right frontal lobe of piglets. First, transcriptional analysis was performed at day 1 or 3 to investigate the dynamic changes in neuroinflammatory gene expression in WM after ICH. Second, ICH piglets were treated either with minocycline or with vehicle alone. All piglets then underwent magnetic resonance imaging to measure brain swelling. Brain tissue was used for real-time polymerase chain reaction (RT-PCR), immunohistochemistry, Western blot, and electron microscopy.

resultsTranscriptional analysis demonstrated that transforming growth factor-β (TGF-β)/mitogen-activated protein kinase (MAPK) signaling is associated with microglia/macrophage-mediated inflammation activation after ICH and is then involved in WM injury after ICH in piglets. Minocycline treatment results in less ICH-induced brain swelling, fewer neurological deficits, and less WM injury in comparison with the vehicle alone. In addition, minocycline reduces microglial activation and alleviates demyelination in white matter after ICH. Finally, we found that minocycline attenuates WM injury by increasing the expression of TGF-β and suppressing MAPK activation after ICH.

conclusionThese results indicate that TGF-β-mediated MAPK signaling contributes to WM injury after ICH, which can be altered by minocycline treatment.

Indexed as

AnimalsAnimals, NewbornBrainBrain InjuriesCerebral HemorrhageMaleMinocyclineSwineWhite MatterMinocyclineintracerebral hemorrhageminocyclinemitogen-activated protein kinasestransforming growth factor-βwhite matter injury

Identifiers

PMID31556245
PMCPMC6776747
OpenAlexW2974931528

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.