ArticleMagnetic resonance in medicine2020
Venous contribution to sodium MRI in the human brain.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Variability by region and method in human brain sodium concentrations estimated byScientific reports · 2023Pooled it
- Quantifying Skin Sodium Concentration With Novel Very Rapid Biexponential TMagnetic resonance in medicine · 2026Article
- Radiosurgery-induced early changes in peritumoral tissue sodium concentration of brain metastases.PloS one · 2024Article
- Brain sodium MRI-derived priors support the estimation of epileptogenic zones using personalized model-based methods in epilepsy.Network neuroscience (Cambridge, Mass.) · 2024Article
- Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy.Human brain mapping · 2023Article
- Imaging the transmembrane and transendothelial sodium gradients in gliomas.Scientific reports · 2021Article
- Assessment of Sodium MRI at 7 Tesla as Predictor of Therapy Response and Survival in Glioblastoma Patients.Frontiers in neuroscience · 2021Article
- Venous contribution to sodium MRI in the human brain.Magnetic resonance in medicine · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeSodium MRI shows great promise as a marker for cerebral metabolic dysfunction in stroke, brain tumor, and neurodegenerative pathologies. However, cerebral blood vessels, whose volume and function are perturbed in these pathologies, have elevated sodium concentrations relative to surrounding tissue. This study aims to assess whether this fluid compartment could bias measurements of tissue sodium using MRI.
methodsDensity-weighted and B
resultsLinear regression demonstrated a significant venous sodium contribution above the underlying tissue signal. The apparent venous sodium concentrations derived from regression were 65.8 ± 4.5 mM (all brain tissue), 71.0 ± 7.4 mM (gray matter), and 55.0 ± 4.7 mM (white matter).
conclusionAlthough the partial vein linear regression did not yield the expected sodium concentration in blood (~87 mM), likely the result of point spread function smearing, this regression highlights that blood compartments may bias brain tissue sodium signals across neurological conditions where blood volumes may differ.
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