ArticlePhotochemistry and photobiology2020
Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT).
Article in Photochemistry and photobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- AAPM Task Group Report 274: Fluence rate dosimetry for photodynamic therapy (PDT).Medical physics · 2025Review
- Three-dimensional printing of the human lung pleural cavity model for PDT malignant mesothelioma.Photodiagnosis and photodynamic therapy · 2024Article
- Treatment planning for photodynamic therapy of abscess cavities using patient-specific optical properties measured prior to illumination.Physics in medicine and biology · 2024Article
- Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.Journal of biomedical optics · 2024Article
- Evaluation of Detector Position and Light Fluence Distribution Using an Infrared Navigation System during Pleural Photodynamic TherapyPhotochemistry and photobiology · 2023Article
- Three-dimensional image-guided topical photodynamic therapy system with light dosimetry dynamic planning and monitoring.Biomedical optics express · 2023Article
- Article
- Augmented Reality Surgical Navigation System for External Ventricular Drain.Healthcare (Basel, Switzerland) · 2022Article
- Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study.Journal of biomedical optics · 2022Article
- Photodynamic therapy in a pleural cavity using monte carlo simulations with 2D/3D Graphical Visualization.Global journal of cancer therapy · 2022Article
- Photodynamic Therapy for Cancer: What's Past is Prologue.Photochemistry and photobiology · 2020Review
- Infrared navigation system for light dosimetry during pleural photodynamic therapy.Physics in medicine and biology · 2020Article
- PDT Light Fluence Phantom Modeling of the Human Pleural Cavity: A Proof-of-Concept Pre-Clinical Study.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- Real-time PDT Dose Dosimetry for Pleural Photodynamic Therapy.Proceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcomes. However, current practice when delivering intrapleural PDT uses a point source to deliver light that is monitored by seven isotropic detectors placed within the pleural cavity to assess its uniformity. We have developed a real-time infrared (IR) tracking camera to follow the movement of the light point source and the surface contour of the treatment area. The calculated light fluence rates were matched with isotropic detectors using a two-correction factor method and an empirical model that includes both direct and scattered light components. Our clinical trial demonstrated that we can successfully implement the IR navigation system in 75% (15/20) of the patients. Data were successfully analyzed in 80% (12/15) patients because detector locations were not available for three patients. We conclude that it is feasible to use an IR camera-based system to track the motion of the light source during PDT and demonstrate its use to quantify the uniformity of light distribution, which deviated by a standard deviation of 18% from the prescribed light dose. The navigation system will fail when insufficient percentage of light source positions is obtained (<30%) during PDT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.