Evidence map›Paper›PMID 31555976›Full record

Trial reportEuropean journal of nutrition2020

EPA and DHA as markers of nutraceutical treatment response in major depressive disorder.

Kiki P van der Burg, Lachlan Cribb, Joseph Firth, Diana Karmacoska, David Mischoulon, Gerard J Byrne, Chad Bousman, Con Stough, Jenifer Murphy, Georgina Oliver and 3 more

Abstract readClinical Trial, Phase IIClinical Trial, Phase IIIMulticenter Study
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Article
  6. Article
  7. Review
  8. Omega-3 Polyunsaturated Fatty Acids in Depression.International journal of molecular sciences · 2024
    Review
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Kiki P van der Burg *MaSc Medicine at University Medical Center Utrecht (UMCU), Utrecht, The Netherlands.
Lachlan Cribb *Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Joseph FirthNICM Health Research Institute, Western Sydney University, Westmead, Australia.
Diana KarmacoskaNICM Health Research Institute, Western Sydney University, Westmead, Australia.
David MischoulonDepression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gerard J ByrneFaculty of Medicine, Discipline of Psychiatry, Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Australia.
Chad BousmanDepartments of Medical Genetics, Psychiatry, and Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
Con StoughCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia.
Jenifer MurphyProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Georgina OliverProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Michael BerkDepartment of Psychiatry, The University of Melbourne, Melbourne, Australia.
Chee H Ng *Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Jerome SarrisProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, The University of Melbourne, Melbourne, Australia. j.sarris@westernsydney.edu.au.ORCID http://orcid.org/0000-0001-9287-8854
The University of Melbourne · AUBarwon Health · AUHarvard University · USSwinburne University of Technology · AUThe University of Queensland · AUUniversity Medical Center Utrecht · NLUniversity of Manchester · GBWestmead Institute · AU

Funding

National Health and Medical Research Council APP1048222
6 · The paper itself

Abstract

purposeDepression clinical trials are increasingly studying biomarkers to predict and monitor response to treatment. Assessment of biomarkers may reveal subsets of patients who are responsive to nutraceutical treatment, which may facilitate a personalized approach to treating depression.

methodsThis is a post hoc analysis of an 8-week, double-blind, randomized, controlled trial (n = 158) investigating a combination nutraceutical comprising Omega-3 (EPA 1 g/DHA 656 mg), SAMe, zinc, 5-HTP, folinic acid, and co-factors versus placebo for the treatment of Major Depressive Disorder. The study explored levels of polyunsaturated fatty acids, folate, vitamin B12, zinc, homocysteine, and BDNF as possible predictors and correlates of response to nutraceutical supplementation.

resultsConcentrations of EPA and DHA in red cell membranes increased in response to treatment and were significantly correlated with a decrease in depressive symptoms during active treatment (p = 0.003 and p = 0.029; respectively). Higher baseline levels of omega-6 fatty acid also correlated with depression reduction in the active treatment group ( p = 0.011). No other biomarkers were associated with a lessening of depressive symptoms.

conclusionChanges in fatty acid levels resulting from a nutraceutical combination containing EPA and DHA provide a response biomarker in treating depression.

Indexed as

Dietary SupplementsAdultBiomarkersDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidErythrocyte MembraneFemaleHumansMajor Depressive DisorderMaleBiomarkersDocosahexaenoic AcidsEicosapentaenoic AcidBiomarkerDepressionNutraceuticalOmega-3Precision medicine

Identifiers

PMID31555976
OpenAlexW2975875128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.