ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2020
Pupillometry measures of autonomic nervous system regulation with advancing age in a healthy pediatric cohort.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06642896 (Quantitative Pupillometry in Brain Injury Children), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Improving children's alertness and neuromuscular response by using a blue-enriched white light in the kindergarten playroom.Scientific reports · 2025Trial
- Association between pupil size and response to atropine therapy in the Atropine Treatment of Myopia study (ATOM2).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Automated pupillometry for the prediction of neurologic outcomes in children requiring extracorporeal membrane oxygenation (ECMO).European journal of pediatrics · 2026Observational
- Temporal variability in pupillary asymmetry reflects ADHD-related traits in preschool and early school-aged children.Frontiers in cognition · 2026Article
- Assessing bedside measures of autonomic nervous system dysregulation in the PICU.Pediatric research · 2025Observational
- Autonomic Nervous System, Cognition, and Emotional Valence During Different Phases of the Menstrual Cycle-A Narrative Review.NeuroSci · 2025Review
- Assessing the Inter-Rater and Inter-Trial Reliability of the NeurOptics Pupillary Light Response-3000 Pupillometer.International journal of sports physical therapy · 2025Article
- The Role of Concussion History and Biological Sex on Pupillary Light Reflex Metrics in Adolescent Rugby Players: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2024Article
- Autonomic nervous system dysfunction in pediatric sport-related concussion: a systematic review.The Journal of the Canadian Chiropractic Association · 2023Article
- How are pupillary parameters affected in pseudoexfoliation syndrome? A quantitative study.International ophthalmology · 2023Article
- Creating a data dictionary for pediatric autonomic disorders.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- From pupil to the brain: New insights for studying cortical plasticity through pupillometry.Frontiers in neural circuits · 2023Review
- PyPlr: A versatile, integrated system of hardware and software for researching the human pupillary light reflex.Behavior research methods · 2022Article
- Do static and dynamic pupillary parameters differ according to childhood, adulthood, and old age? A quantitative study in healthy volunteers.Indian journal of ophthalmology · 2022Article
- Evolution of physiologic and autonomic phenotype in rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation over a decade from age at diagnosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Increasing Vegetable Diversity Consumption Impacts the Sympathetic Nervous System Activity in School-Aged Children.Nutrients · 2021Article
- Pupillometry measurement and its relationship to retinal structural changes in children with attention deficit hyperactivity disorder.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- The future of quantitative pupillometry in health and disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
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Authors and funding
30 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine if variables of the pupillary light response mature with age and sex in a healthy pediatric cohort and the utility of pupillometry in assessment among pediatric participants.
methodsAfter 1 min in a dark room to establish baseline, pupillometry was performed on 323 healthy, pediatric participants (646 eyes; 2-21 years; 175 females). Variables included initial pupil diameter, pupil diameter after light stimulus, percent pupillary constriction, latency to onset of constriction, average constriction velocity, maximum constriction velocity, average dilation velocity, and time from light stimulus to 75% of the initial pupil diameter. Data analyses employed ANOVAs and non-linear regressions.
resultsAnalyses of age group differences revealed that participants 12-21 years old had a larger initial pupil diameter and pupil diameter after light stimulus, with males aged 12-18 years demonstrating a larger pupil diameter than all younger participants (ps < 0.05). Participants 12-18 years old had a slower maximum constriction velocity than participants 6-11 years old, with no sex differences (ps < 0.05). Furthermore, males aged 12-18 years old had a smaller percent constriction than males 6-11 years old (ps < 0.05). Regressions revealed that percent constriction and dilation velocity seemed to mature linearly, initial pupil diameter and ending pupil diameter matured quadratically, and the constriction velocity terms matured cubically.
conclusionsResults revealed maturation of the pupillary light response by age and sex in healthy pediatric participants. Given the value of the pupillary light response as a biomarker, the results provide normative benchmarks for comparison in health and disease, including opiate-exposed and concussion patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.