ArticleScience advances2019
BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers.
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Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
59 citing papers in PubMed, 85 citations in OpenAlex.
- The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma.Nature communications · 2021Trial
- Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma.Molecular medicine (Cambridge, Mass.) · 2026Article
- A tailored in vivo CRISPR screen identifies BAP1 as a potent tumor suppressor of sarcoma.JCI insight · 2026Article
- Gene therapy for uveal melanoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Article
- Germline inactivation of tumor suppressor BAP1 is associated with white spotting.The Journal of clinical investigation · 2026Article
- CD2 costimulation strength: A key regulator of T cell function and anti-tumor immunity that is epigenetically regulated.iScience · 2025Article
- Identification of targetable epigenetic vulnerabilities for uveal melanoma.Cell death & disease · 2025Article
- Characterization of BRCA1-Associated Protein-1 (BAP1) Aggregation Properties Induced by Cancer-Associated Mutations.Chembiochem : a European journal of chemical biology · 2025Article
- Restoration of BAP1 activity via base editing suppresses anchorage-independent survival in kidney cancer.Cancer cell international · 2025Article
- Identification of two distinct uveal melanoma subtypes based on the immune cell infiltration of the primary tumour.Cancer immunology, immunotherapy : CII · 2025Article
- Current Therapies and Potential Strategies for Uveal Melanoma.Drugs and drug candidates · 2025Article
- Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis.Nature communications · 2025Article
- An overview of BAP1 biological functions and current therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2025Review
- Expanded detection and impact ofNAR cancer · 2024Article
- Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.Nature genetics · 2024Article
- Understanding the intersection between placental development and cancer: Lessons from the tumor suppressor BAP1.Communications biology · 2024Review
- Histone H2A deubiquitinase BAP1 is essential for endothelial cell differentiation from human pluripotent stem cells.In vitro cellular & developmental biology. Animal · 2024Article
- Identification of mitophagy-related hub genes during the progression of spinal cord injury by integrated multinomial bioinformatics analysis.Biochemistry and biophysics reports · 2024Article
- BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system.The Journal of clinical investigation · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Jeffim N KuznetsovBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-6197-2642
Tristan H AgueroDepartment of Cell Biology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-5651-5316
Dawn A OwensBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0003-4661-2718
Stefan KurtenbachBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-7445-596X
Matthew G FieldBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-3459-376X
Michael A DuranteBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0003-3137-6847
Daniel A RodriguezBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0001-7682-6106
Mary Lou KingDepartment of Cell Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
J William HarbourBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-1104-9809
Stem Cell Institute · PAUniversity of Miami · US
Funding
Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Olveen Carrasquillo · 2019 to 2026
$24.1MShared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2MMOLECULAR PREDICTIVE TESTING IN OCULAR MELANOMAR01CA125970 · NCI · WASHINGTON UNIVERSITY · PI CORREA, ZELIA MARIA, HARBOUR, JAMES WILLIAM · 2006 to 2021
$4.9MRole of Translational Regulators Nanos and Dazl in Preserving TotipotencyR01GM102397 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KING, MARY LOU · 2013 to 2016
$1.5MCancer Epigenetics Training ProgramT32CA217835 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FIGUEROA, MARIA EUGENIA, MOREY, LLUIS · 2018 to 2022
$1.3MThe role of PRAME in promoting metastasis in uveal melanomaF30CA206430 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FIELD, MATTHEW GARRETT · 2016 to 2018
$147kEpigenetic deregulation and tumor progression due to the loss of a novel interaction between HDAC1 and BAP1 in uveal melanomaF31CA243426 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RODRIGUEZ, DANIEL ALEXANDER · 2019 to 2021
$143kNCI NIH HHS F30 CA206430NCI NIH HHS F31 CA243426NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA125970NCI NIH HHS T32 CA217835NEI NIH HHS P30 EY014801NIGMS NIH HHS R01 GM102397
Abstract
The BAP1 tumor suppressor is mutated in many human cancers such as uveal melanoma, leading to poor patient outcome. It remains unclear how BAP1 functions in normal biology or how its loss promotes cancer progression. Here, we show that Bap1 is critical for commitment to ectoderm, mesoderm, and neural crest lineages during
Indexed as
Cell DifferentiationEpigenesis, GeneticGene Expression Regulation, NeoplasticTranscriptional ActivationAnimalsCell Line, TumorHistone DeacetylasesHumansMelanomaMice, Inbred NODMice, SCIDRepressor ProteinsTumor Suppressor ProteinsUbiquitin ThiolesteraseUveal NeoplasmsXenopus laevisBAP1 protein, humanHDAC4 protein, humanHistone DeacetylasesRepressor ProteinsTumor Suppressor ProteinsUbiquitin Thiolesterase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.