ReviewFrontiers in veterinary science2019
Large Animal Models for Anterior Cruciate Ligament Research.
Review in Frontiers in veterinary science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cross-species transcriptome-wide meta-analysis of anterior cruciate ligament rupture.BMC genomics · 2025Pooled it
- The Addition of Posterolateral Tenodesis in Isolated PCL Injuries and in Combination With Fanelli Type A Lesion of the Posterolateral Corner Decreases Rotatory Instability: A Biomechanical Study in Human Cadaveric Knees.Orthopaedic journal of sports medicine · 2026Article
- Collagen-elastin microstructural network and its mechanical implications in the anterior cruciate ligament: A feasibility study.Journal of orthopaedic surgery and research · 2026Article
- Morphometric analysis of rat and mouse musculoskeletal tissues using high field MRI.Scientific reports · 2025Article
- A new preclinical sheep model of medial meniscus anterior root repair: Part 1-Quantitative morphology and relationships to adjacent structures.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Time-dependent changes in medial meniscus kinematics and attachment strength after anterior root injury and repair in a large animal model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Dynamic Deformation Behavior of the Porcine Anterior Cruciate Ligament Enthesis Under Anterior Tibial Loading.Annals of biomedical engineering · 2025Article
- Effects of various load magnitudes on ACL: an in vitro study using adolescent porcine stifle joints.Journal of orthopaedic surgery and research · 2024Article
- [Research progress on bioactive strategies for promoting tendon graft healing after anterior cruciate ligament reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Review
- Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- Anatomical Tissue Engineering of the Anterior Cruciate Ligament Entheses.International journal of molecular sciences · 2023Review
- Correlation between morphological features of the anterior cruciate ligament: A quantitative study using a porcine model.Frontiers in veterinary science · 2023Article
- Review
- Canine ACL rupture: a spontaneous large animal model of human ACL rupture.BMC musculoskeletal disorders · 2022Review
- Remnants-preserving ACL reconstruction using direct tendinous graft fixation: a new rat model.Journal of orthopaedic surgery and research · 2022Article
- Comparison of the morphology of the anterior cruciate ligament and related bony structures between pigs and humans.Frontiers in veterinary science · 2022Article
- MSC therapy in livestock models.Translational animal science · 2022Review
- The Prognosis of Arthrofibroses: Prevalence, Clinical Shortcomings, and Future Prospects.Trends in pharmacological sciences · 2021Review
- A Translational Porcine Model for Human Cell-Based Therapies in the Treatment of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Injury.The American journal of sports medicine · 2020Article
- Decellularized porcine xenograft for anterior cruciate ligament reconstruction: A histological study in sheep comparing cross-pin and cortical suspensory femoral fixation.Bone & joint research · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large animal (non-rodent mammal) models are commonly used in ACL research, but no species is currently considered the gold standard. Important considerations when selecting a large animal model include anatomical differences, the natural course of ACL pathology in that species, and biomechanical differences between humans and the chosen model. This article summarizes recent reports related to anatomy, pathology, and biomechanics of the ACL for large animal species (dog, goat, sheep, pig, and rabbit) commonly used in ACL research. Each species has unique features and benefits as well as potential drawbacks, which are highlighted in this review. This information may be useful in the selection process when designing future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.