ReviewJournal of bone metabolism2019
Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment.
Review in Journal of bone metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Medication for bone loss in female patients with anorexia nervosa: a systematic review and management algorithm.Eating and weight disorders : EWD · 2025Pooled it
- Carbonyl stress markers are associated with binge-eating/purging behavior of anorexia nervosa: A pilot study.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Variation in the diagnosis and management of functional hypothalamic amenorrhea across clinical specialties: A nationwide cross-sectional survey in China.The Journal of international medical research · 2026Article
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- Osteoporosis in Pre-menopausal Patients With Anorexia Nervosa: Management, Challenges and Review of Literature.Cureus · 2025Article
- Anorexia nervosa-an update.Der Nervenarzt · 2025Review
- [Anorexia nervosa-An update. German version].Der Nervenarzt · 2025Review
- Article
- Bone health in avoidant/restrictive food intake disorder: a narrative review.Journal of eating disorders · 2023Review
- Pharmacotherapy in anorexia nervosa: A Danish nation-wide register-based study.Journal of psychosomatic research · 2023Article
- Transition of young adults with metabolic bone diseases to adult care.Frontiers in endocrinology · 2023Review
- Recommendations for Improving Women's Bone Health Throughout the Lifespan.Journal of women's health (2002) · 2022Article
- Associations between bone mineral density, body composition and amenorrhoea in females with eating disorders: a systematic review and meta-analysis.Journal of eating disorders · 2022Review
- Adipose tissue in bone regeneration - stem cell source and beyond.World journal of stem cells · 2022Review
- Secondary Osteoporosis and Metabolic Bone Diseases.Journal of clinical medicine · 2022Review
- Therapeutic Treatments for Osteoporosis-Which Combination of Pills Is the Best among the Bad?International journal of molecular sciences · 2022Review
- Bone health in functional hypothalamic amenorrhea: What the endocrinologist needs to know.Frontiers in endocrinology · 2022Review
- Anorexia nervosa: COVID-19 pandemic period (Review).Experimental and therapeutic medicine · 2021Review
- The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis.Frontiers in endocrinology · 2021Review
- [Zoledronate regulates osteoclast differentiation and bone resorption in high glucose through p38 MAPK pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to disease management. Available research suggests that low body weight and decreased gonadal function are the strongest predictors of bone loss and fractures in patients with AN. Additionally, other metabolic disturbances have been linked to bone loss, including growth hormone resistance, low leptin concentrations, and hypercortisolemia, but those correlations are less consistent and lack evidence of causality. In terms of treatment of AN-related bone disease, weight gain has the most robust impact on bone mineral density (BMD). Restoration of gonadal function seems to augment this effect and may independently improve BMD. Bisphosphonates, insulin-like growth factor 1 supplementation, and teriparatide may also be reasonable considerations, however need long-term efficacy and safety data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.