ArticleTranslational lung cancer research2019
Incidence, prognostic factors, and a nomogram of lung cancer with bone metastasis at initial diagnosis: a population-based study.
Article in Translational lung cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of bone metastasis on the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Pooled it
- Development and Validation of a Prognostic Model to Predict Overall Survival for Lung Adenocarcinoma: A Population-Based Study From the SEER Database and the Chinese Multicenter Lung Cancer Database.Technology in cancer research & treatmentTrial
- Review
- Prognostic nutritional index improved the survival prediction of the revised Tokuhashi and Tomita scores for patients with lung cancer spinal metastases.BMC cancer · 2026Article
- Predicting lung cancer bone metastasis using CT and pathological imaging with a Swin Transformer model.Journal of bone oncology · 2025Article
- Development of a nomogram for overall survival prediction in primary upper lobe lung cancer patients: A SEER population-based analysis.PloS one · 2025Article
- Lung cancer exosomal Gal3BP promotes osteoclastogenesis with potential connotation in osteolytic metastasis.Scientific reports · 2024Article
- A prognostic framework for predicting lung signet ring cell carcinoma via a machine learning based cox proportional hazard model.Journal of cancer research and clinical oncology · 2024Article
- ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer.The clinical respiratory journal · 2024Article
- Development of a haematological indices-based nomogram for prognostic prediction and immunotherapy response assessment in primary pulmonary lymphoepithelioma-like carcinoma patients.Translational lung cancer research · 2024Article
- Prognostic factors and predictive model construction in patients with non-small cell lung cancer: a retrospective study.Frontiers in oncology · 2024Article
- Nomogram model of survival prediction for nasopharyngeal carcinoma with lung metastasis: developed from the SEER database and validated externally.Frontiers in oncology · 2024Article
- Bone metastasis in non-small-cell lung cancer: genomic characterization and exploration of potential targets.Therapeutic advances in medical oncology · 2024Article
- Chinese expert consensus on the diagnosis and treatment of bone metastasis in lung cancer (2022 edition).Journal of the National Cancer Center · 2023Article
- Development and validation of a nomogram for predicting the overall survival in non-small cell lung cancer patients with liver metastasis.Translational cancer research · 2023Article
- The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression.Biomolecules · 2023Review
- Risk factors and prognostic nomogram for patients with second primary cancers after lung cancer using classical statistics and machine learning.Clinical and experimental medicine · 2023Article
- Article
- A radiomics nomogram prediction for survival of patients with "driver gene-negative" lung adenocarcinomas (LUAD).La Radiologia medica · 2023Article
- Survival benefit of resection surgery for lung adenocarcinoma with bone metastases and a post-operative prognosis nomogram establishment and validation.Journal of thoracic disease · 2022Article
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9 authors.
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Abstract
backgroundBone is one of the common metastatic sites of lung cancer, and its prognosis is not optimistic. We performed a study to evaluate the incidence, survival, and prognostic factors of lung cancer with bone metastasis (LCBM) at initial diagnosis, and to develop a nomogram to predict its outcomes.
methodsWe conducted a retrospective study choosing 13,541 patients with LCBM from the Surveillance, Epidemiology, and End Results (SEER) 18 registry database. An X-tile analysis provided the optimal age cutoff point. The incidence, overall survival, and prognosis of bone metastasis were evaluated according to the patient information, characteristics of the tumor, and therapy. We also used multivariable Cox regression to estimate mortality hazard ratios (HRs) among patients with LCBM, while a visual nomogram was established to judge the prognosis.
resultsThe incidence of disease increased with age, but survival rates show the opposite trend. The median survival time was about 4 months. In addition, although the differences for patient race is not significant (P=0.445), White patients are prone to have bone metastases from lung cancer according to the incidence analysis. The difference for laterality is also not significant (P=0.534), while the factors of age, gender, the total number of sites, histological types, grade, tumor size, and treatment are significantly related to the outcome of patients with LCBM. Furthermore, our nomogram could predict the probability of surviving to the median survival time of the population with a c-index of 0.72.
conclusionsAge, characteristics of the tumor, and therapy should be considered for prediction of prognosis for patients with lung cancer bone metastasis. Putatively, the younger patients and the patients with chemotherapy and surgery may indicate improved survival.
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