Evidence map›Paper›PMID 31555452›Full record

ArticleNeuro-oncology practice2019

David B Altshuler, Lin Wang, Lili Zhao, Zachary Miklja, Joey Linzey, Amanda Brezzell, Sofia Kakaizada, Saritha Krishna, Daniel A Orringer, Emily M Briceño and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Neurotoxicity from Old and New Radiation Treatments for Brain Tumors.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Exercise improves health-related quality of life sleep and fatigue domains in adult high- and low-grade glioma patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

David B AltshulerDepartment of Neurosurgery, University of Michigan, Ann Arbor, USA.
Lin WangDepartment of Neurosurgery, University of Michigan, Ann Arbor, USA.
Lili ZhaoDepartment of Biostatistics, University of Michigan, Ann Arbor, USA.
Zachary MikljaDepartment of Neurosurgery, University of Michigan, Ann Arbor, USA.
Joey LinzeyDepartment of Neurosurgery, University of Michigan, Ann Arbor, USA.
Amanda BrezzellDepartment of Neurosurgery, University of Michigan, Ann Arbor, USA.
Sofia KakaizadaDepartment of Neurosurgery, University of California San Francisco, USA.
Saritha KrishnaDepartment of Neurosurgery, University of California San Francisco, USA.
Daniel A OrringerDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, USA.
Emily M BriceñoDepartment of Neurosurgery, Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA.
Nicolette GabelDepartment of Neurosurgery, Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA.
Shawn L Hervey-JumperDepartment of Neurosurgery, University of Michigan, Ann Arbor, USA.
University of Michigan–Ann Arbor · USUniversity of California, San Francisco · US

Funding

SF BUILD: Enabling Students to Represent in ScienceTL4GM118986 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2022
$5.4M
National Longitudinal Evaluation of the RISE ProgramR01GM075316 · NIGMS · CALIFORNIA STATE UNIVERSITY SAN MARCOS · PI ESTRADA, MICA BETH, SCHULTZ, PAUL WESLEY · 2005 to 2016
$4.9M
Intratumoral functional connectivity with implications on synaptogenesis and aphasia recovery in adult astrocytic WHO II-III gliomaK08NS110919 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERVEY-JUMPER, SHAWN L. · 2019 to 2023
$1.0M
NIGMS NIH HHS R01 GM075316NIGMS NIH HHS TL4 GM118986NINDS NIH HHS K08 NS110919
6 · The paper itself

Abstract

backgroundCognitive and language dysfunction is common among patients with glioma and has a significant impact on survival and health-related quality of life (HRQOL). Little is known about the factors that make individual patients more or less susceptible to the cognitive sequelae of the disease. A better understanding of the individual and population characteristics related to cognitive function in glioma patients is required to appropriately stratify patients, prognosticate, and develop more efficacious treatment regimens. There is evidence that allelic variation among genes involved in neurotransmission and synaptic plasticity are related to neurocognitive performance in states of health and neurologic disease.

methodsWe studied the association of single-nucleotide polymorphism variations in brain-derived neurotrophic factor (

resultsPatients with higher-performing alleles have better scores on neurocognitive testing with the Repeatable Battery for the Assessment of Neuropsychological Status and Stroop test, but not the Trail Making Test.

conclusionsA better understanding of the genetic contributors to neurocognitive performance in glioma patients and capacity for functional recovery is necessary to develop improved treatment strategies based on patient-specific factors.

Indexed as

cognitiongliomahealth-related quality of lifelanguagereturn to work

Identifiers

PMID31555452
PMCPMC6753359
OpenAlexW2940177694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.