Evidence map›Paper›PMID 31555304›Full record

ArticleFrontiers in immunology2019

Enhanced Neutrophil Immune Homeostasis Due to Deletion of PHLPP.

Taojing Ran, Yao Zhang, Na Diao, Shuo Geng, Keqiang Chen, Christina Lee, Liwu Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. PHLPP Signaling in Immune Cells.Current topics in microbiology and immunology · 2022
    Review
  5. Review
  6. PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling.Annual review of pharmacology and toxicology · 2021
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Taojing RanDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Yao ZhangDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Na DiaoDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Shuo GengDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Keqiang ChenDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Christina LeeTranslational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, VA, United States.
Liwu LiDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Virginia Tech · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils are known to adopt dynamic and distinct functional phenotypes involved in the modulation of inflammation and immune homeostasis. However, inter-cellular signaling mechanisms that govern neutrophil polarization dynamics are not well understood. Employing a novel model of PHLPP deficient mice, we examined how neutrophils deficient in PHLPP may uniquely modulate immune defense and the host response during acute colitis. We found that PHLPP

Indexed as

AnimalsColitisDextran SulfateHomeostasisMiceMice, Inbred C57BLMice, KnockoutNeutrophil InfiltrationNeutrophilsPhosphoprotein PhosphatasesDextran SulfatePHLPP1 protein, mousePhosphoprotein Phosphatasescolitisimmune dynamicsinflammationneutrophilsPHLPP

Identifiers

PMID31555304
PMCPMC6742689
OpenAlexW2969394307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.