Evidence map›Paper›PMID 31555275›Full record

ArticleFrontiers in immunology2019

TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells.

Doaa Tawfik, Christopher Groth, Jan-Paul Gundlach, Matthias Peipp, Dieter Kabelitz, Thomas Becker, Hans-Heinrich Oberg, Anna Trauzold, Daniela Wesch

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
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  4. Immunotherapy in central nervous system tumors.International journal of surgery (London, England) · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. The therapeutic role of γδT cells in TNBC.Frontiers in immunology · 2024
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Doaa TawfikInstitute for Experimental Cancer Research, Christian-Albrechts-University of Kiel, Kiel, Germany.
Christopher GrothInstitute for Experimental Cancer Research, Christian-Albrechts-University of Kiel, Kiel, Germany.
Jan-Paul GundlachInstitute for Experimental Cancer Research, Christian-Albrechts-University of Kiel, Kiel, Germany.
Matthias PeippDivision of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, UKSH, CAU Kiel, Kiel, Germany.
Dieter KabelitzInstitute of Immunology, University Hospital Schleswig-Holstein, Christian-Albrechts University of Kiel, Kiel, Germany.
Thomas BeckerDepartment of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, UKSH, Campus Kiel, Kiel, Germany.
Hans-Heinrich ObergInstitute of Immunology, University Hospital Schleswig-Holstein, Christian-Albrechts University of Kiel, Kiel, Germany.
Anna TrauzoldInstitute for Experimental Cancer Research, Christian-Albrechts-University of Kiel, Kiel, Germany.
Daniela WeschInstitute of Immunology, University Hospital Schleswig-Holstein, Christian-Albrechts University of Kiel, Kiel, Germany.
Kiel University · DEUniversity of Lübeck · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired immune evasion is one of the mechanisms that contributes to the dismal prognosis of cancer. Recently, we observed that different γδ T cell subsets as well as CD8

Indexed as

Cytotoxicity, ImmunologicImmunomodulationBiomarkersCell Line, TumorCyclooxygenase 1Cyclooxygenase 2DinoprostoneGene Knockdown TechniquesHumansNeoplasmsReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesTumor Necrosis Factor Decoy ReceptorsBiomarkersCyclooxygenase 1Cyclooxygenase 2DinoprostonePTGS1 protein, humanReceptors, Antigen, T-Cell, gamma-deltaTNFRSF10D protein, humanTumor Necrosis Factor Decoy Receptorsbispecific AbCOX (cyclooxygenase)granzyme Bpancreatic cancerPGE2TRAILTRAIL-receptor 4γδ T cell-cytotoxicity

Identifiers

PMID31555275
PMCPMC6722211
OpenAlexW2968651495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.