Evidence map›Paper›PMID 31555194›Full record

ArticleFrontiers in neurology2019

The Role of Very Low Level Blast Overpressure in Symptomatology.

Venkata Siva Sai Sujith Sajja, Christina LaValle, Jonathan E Salib, Anthony C Misistia, Meron Y Ghebremedhin, Alejandro N Ramos, Michael Joseph Egnoto, Joseph B Long, Gary H Kamimori

Abstract read
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Mitigation of Hearing Damage After Repeated Blast Exposures in Animal Model of Chinchilla.Journal of the Association for Research in Otolaryngology : JARO · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Venkata Siva Sai Sujith SajjaBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Christina LaValleBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Jonathan E SalibBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Anthony C MisistiaBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Meron Y GhebremedhinBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Alejandro N RamosBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Michael Joseph EgnotoBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Joseph B LongBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Gary H KamimoriBlast-Induced NeuroTrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blast overpressure exposure has been linked to transient, but measurably deteriorated performance and symptomatologies in law enforcement and military personnel. Overlapping sub-concussive symptomatology associated with the very low level blast overpressures (vLLB) but high sound pressure (<3 psi) associated with these exposures has largely been ignored. Notably, the current vLLB or acoustic literature has focused exclusively on auditory defects, and has not addressed the broader concerns of Soldier health and readiness. This work was prompted by reports of symptomatology such as headache, nausea, slowed reaction time, and balance/hearing complications among personnel undergoing frequent exposures to low overpressure accompanied by high acoustic pressures. To more fully address the consequences associated with low overpressure exposures (<3 psi), a pilot proof-of-concept study was implemented, and data was acquired at two sites on the Fort Benning grenade course range. Findings indicated overpressures ranged from 0.14 to 0.42 psi (0.97-2.89 kPa) at range 1 and 0.22-0.30 psi (1.52-2.07 kPa) on range 2 of the grenade course. Corresponding sound-meter data varied from 153.72 to 163.22 dBP. Headache and long think were the most frequently reported symptoms (3/6 instructors), with lightheadedness, ringing of the ears, restlessness, frustration, and irritability also increasing in 2/6 of the instructors post exposure. Long think (prolonged thinking), ringing of the ears, restlessness, and irritability were the most severe symptoms, with the highest reported post exposure value rating a 3 on the 0-4-point scale. We demonstrate that low-level repeated overpressure exposure can result in transient symptomatology that overlaps with sub-concussive like effects.

Indexed as

blastbTBImTBIoverpressuresound pressuresymptomology

Identifiers

PMID31555194
PMCPMC6722183

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.