ArticleNature2019
FHL1 is a major host factor for chikungunya virus infection.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
16.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Visualized analysis of core themes and emerging frontiers in global chikungunya virus studies.Frontiers in microbiology · 2025Pooled it
- O'nyong-nyong virus adaptive mutations in non-structural protein 1 and 3 enhance RNA replication and overcome FHL1 requirement.Emerging microbes & infections · 2026Article
- Research progress on the role of host factors in Chikungunya virus infection and intervention strategies.Virulence · 2026Review
- Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering.Journal of virology · 2026Review
- Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay.Journal of virology · 2026Review
- Review
- Research advances in chikungunya virus: Epidemiology, pathogenesis, and control.One health (Amsterdam, Netherlands) · 2026Review
- The SMARCA4-TMEM47 axis plays an essential role in chikungunya virus RNA replication.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Chikungunya Virus in 2025: Epidemiology, Immunopathogenesis, and Vaccine Development - A Narrative Review.Infection and drug resistance · 2026Review
- Replicon-based genome-wide CRISPR knockout screening for the identification of host factors involved in viral replication.Nature communications · 2025Article
- Time-Resolved Analysis of Protein-Protein Ensembles Using a Destabilizing Domain to Map Dynamic Interactions of SARS-CoV-2 nsp15.ACS chemical biology · 2025Article
- Chikungunya virus and other emerging arthritogenic alphaviruses.Nature reviews. Microbiology · 2025Review
- IFITM proteins are key entry factors for porcine epidemic diarrhea coronavirus.Journal of virology · 2025Article
- Article
- Proximity interactome of alphavirus replicase component nsP3 includes proviral host factors eIF4G and AHNAK.PLoS pathogens · 2025Article
- Pathogenesis and clinical management of arboviral diseases.World journal of virology · 2025Review
- Infectomics of Chikungunya Virus: Roles Played by Host Factors.The American journal of tropical medicine and hygiene · 2025Review
- YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses.Journal of virology · 2025Article
- Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health.Pathogens (Basel, Switzerland) · 2025Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 14 institutions in 2 countries.
Laurent Meertens *INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France. laurent.meertens@inserm.fr.
Mohamed Lamine HafirassouINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France.
Thérèse CoudercInstitut Pasteur, Inserm U1117, Biology of Infection Unit, Paris, France.
Lucie Bonnet-MadinINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France.
Vasiliya KrilINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France.
Beate M KümmererInstitute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Athena LabeauINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France.
Alexis BrugierINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France.
Etienne Simon-LoriereInstitut Pasteur, G5 Evolutionary Genomics of RNA Viruses, Paris, France.
Julien Burlaud-GaillardINSERM U1259 MAVIVH et Plateforme IBiSA de Microscopie Electronique, Université de Tours et CHRU de Tours, Tours, France.
Cécile DoyenInstitut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS-Université de Montpellier, Montpellier, France.
Laura PezziUnité des Virus Émergents, Aix-Marseille Univ, IRD190, Inserm 1207, EFS-IRBA, Marseille, France.
Thibaud GoupilInstitut Pasteur, Inserm U1117, Biology of Infection Unit, Paris, France.
Sophia RafasseInstitut Pasteur, Inserm U1117, Biology of Infection Unit, Paris, France.
Pierre-Olivier VidalainEquipe Chimie & Biologie, Modélisation et Immunologie pour la Thérapie, Université Paris Descartes, CNRS UMR 8601, Paris, France.
Anne Bertrand-LegoutCenter of Research in Myology, Sorbonne Université, INSERM UMRS974, Paris, France.
Lucie GueneauCenter of Research in Myology, Sorbonne Université, INSERM UMRS974, Paris, France.
Raul Juntas-MoralesDépartement de Neurologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.
Rabah Ben YaouCenter of Research in Myology, Sorbonne Université, INSERM UMRS974, Paris, France.
Gisèle BonneCenter of Research in Myology, Sorbonne Université, INSERM UMRS974, Paris, France.
Xavier de LamballerieUnité des Virus Émergents, Aix-Marseille Univ, IRD190, Inserm 1207, EFS-IRBA, Marseille, France.
Monsef BenkiraneInstitut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS-Université de Montpellier, Montpellier, France.
Philippe RoingeardINSERM U1259 MAVIVH et Plateforme IBiSA de Microscopie Electronique, Université de Tours et CHRU de Tours, Tours, France.
Constance DelaugerreINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France.
Marc LecuitInstitut Pasteur, Inserm U1117, Biology of Infection Unit, Paris, France.
Ali Amara *INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France. ali.amara@inserm.fr.
Hôpital Saint-Louis · FRInserm · FRCentre National de la Recherche Scientifique · FRInstitut Pasteur · FRUniversité de Tours · FRAix-Marseille Université · FRBiology of Infection · FRCentre de Recherche en MyologieCentre Hospitalier Universitaire de Montpellier · FRLaboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques · FRSorbonne Université · FRUniversité de Montpellier · FRUniversité Paris Cité · FRUniversity of Bonn · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chikungunya virus (CHIKV) is a re-emerging alphavirus that is transmitted to humans by mosquito bites and causes musculoskeletal and joint pain
Indexed as
Host-Pathogen InteractionsAnimalsCells, CulturedChikungunya FeverChikungunya virusFemaleFibroblastsHEK293 CellsHost-Derived Cellular FactorsHumansIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMaleMiceMuscle ProteinsMyoblastsFHL1 protein, humanHost-Derived Cellular FactorsIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle Proteinsnsp3 protein, alphavirusRNA, ViralViral Nonstructural Proteins
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.