Evidence map›Paper›PMID 31554905›Full record

ArticleScientific reports2019

Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength.

Alexandra Aguilar-Perez, Rafael Pacheco-Costa, Emily G Atkinson, Padmini Deosthale, Hannah M Davis, Alyson L Essex, Julian E Dilley, Leland Gomez, Joseph E Rupert, Teresa A Zimmers and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Molecular communication from bone to skeletal muscle: an overview.Frontiers in cell and developmental biology · 2025
    Review
  2. Independent contribution of gonads and sex chromosomes to sex differences in bone mass and strength in the four-core genotypes mouse model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Research Progress in Skin Aging, Metabolism, and Related Products.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Alexandra Aguilar-PerezDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Rafael Pacheco-CostaDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Emily G AtkinsonDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Padmini DeosthaleDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Hannah M DavisDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Alyson L EssexDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Julian E DilleyDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0002-9282-3412
Leland GomezDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Joseph E RupertDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Teresa A ZimmersDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0001-7872-0540
Roger J ThompsonHotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada.
Matthew R AllenDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Lilian I PlotkinDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. lplotkin@iupui.edu.ORCID http://orcid.org/0000-0002-9537-4544
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USIndiana University Health · USUniversity of Calgary · CA

Funding

Comprehensive Training Program in Musculoskeletal ResearchT32AR065971 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ALEXANDER G ROBLING · 2015 to 2026
$4.4M
Osteocyte Apoptosis and Regulation of Bone Resorption with AgingR01AR067210 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI PLOTKIN, LILIAN IRENE · 2015 to 2019
$1.9M
Connexin 43 Hemichannels and Signaling In BoneR01AR053643 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI PLOTKIN, LILIAN IRENE · 2008 to 2012
$1.6M
PQB3: Mechanisms & Targeting of Sonic Hedgehog Signaling in Muscle Wasting of Cancer CachexiaR01CA194593 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI ZIMMERS, TERESA A · 2015 to 2018
$1.4M
Molecular Mechanisms of Muscle and Fat Wasting in Pancreatic Cancer CachexiaI01BX004177 · VA · RLR VA MEDICAL CENTER · PI ZIMMERS, TERESA A · 2018 to 2021
–
BLRD VA I01 BX004177NCI NIH HHS R01 CA194593NIAMS NIH HHS R01 AR053643NIAMS NIH HHS T32 AR065971U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 3R01AR067210-03S1
6 · The paper itself

Abstract

Pannexins (Panxs), glycoproteins that oligomerize to form hemichannels on the cell membrane, are topologically similar to connexins, but do not form cell-to-cell gap junction channels. There are 3 members of the family, 1-3, with Panx1 being the most abundant. All Panxs are expressed in bone, but their role in bone cell biology is not completely understood. We now report that osteocytic Panx1 deletion (Panx1

Indexed as

AnimalsBody Mass IndexBone and BonesConnexinsFemaleMaleMiceMuscle, SkeletalMuscle StrengthMuscular DiseasesNerve Tissue ProteinsOsteocytesConnexinsNerve Tissue ProteinsPanx1 protein, mouse

Identifiers

PMID31554905
PMCPMC6761284
OpenAlexW2975517146

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.