ArticleScientific reports2019
Sensory sensitivity as a link between concussive traumatic brain injury and PTSD.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Transdiagnostic neural correlates of post-traumatic stress disorder and mild traumatic brain injury.Brain communications · 2026Article
- Mild Traumatic Brain Injury Impairs Fear Extinction and Network Excitability in the Infralimbic Cortex.Journal of neurotrauma · 2025Article
- The network-based underpinnings of persisting symptoms after concussion: a multimodal neuroimaging meta-analysis.Nature. Mental health · 2025Article
- Exploring the Impact of Mitoquinone Supplementation on Glycan Profiles in a Repeated Mild Traumatic Brain Injury Mouse Model.Neurotrauma reports · 2025Article
- Biomarkers and Endophenotypes of Post-traumatic Headaches.Current pain and headache reports · 2024Review
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- A review of brain regions and associated post-concussion symptoms.Frontiers in neurology · 2023Review
- Examining the long-term effects of traumatic brain injury on fear extinction in male rats.Frontiers in behavioral neuroscience · 2023Article
- Review
- Increased Fear Generalization and Amygdala AMPA Receptor Proteins in Chronic Traumatic Brain Injury.Journal of neurotrauma · 2022Article
- Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders.Biological psychiatry · 2022Review
- Emotional scene remembering: A combination of disturbing and facilitating effects of emotion?Frontiers in behavioral neuroscience · 2022Article
- Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI.Frontiers in rehabilitation sciences · 2022Article
- Models for Treating Post-traumatic Headache.Current pain and headache reports · 2021Review
- Region-Dependent Modulation of Neural Plasticity in Limbic Structures Early after Traumatic Brain Injury.Neurotrauma reports · 2021Article
- Neuroimaging and advanced research techniques may lead to improved outcomes in military members suffering from traumatic brain injury.Trauma surgery & acute care open · 2021Review
- A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury.Frontiers in behavioral neuroscience · 2021Review
- Sex Differences in Behavioral Sensitivities After Traumatic Brain Injury.Frontiers in neurology · 2020Article
- Article
- Fear, defense, and emotion: A neuroethological understanding of the negative valence research domain criteria.The American psychologistArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) is one of the most common injuries to military personnel, a population often exposed to stressful stimuli and emotional trauma. Changes in sensory processing after TBI might contribute to TBI-post traumatic stress disorder (PTSD) comorbidity. Combining an animal model of TBI with an animal model of emotional trauma, we reveal an interaction between auditory sensitivity after TBI and fear conditioning where 75 dB white noise alone evokes a phonophobia-like phenotype and when paired with footshocks, fear is robustly enhanced. TBI reduced neuronal activity in the hippocampus but increased activity in the ipsilateral lateral amygdala (LA) when exposed to white noise. The white noise effect in LA was driven by increased activity in neurons projecting from ipsilateral auditory thalamus (medial geniculate nucleus). These data suggest that altered sensory processing within subcortical sensory-emotional circuitry after TBI results in neutral stimuli adopting aversive properties with a corresponding impact on facilitating trauma memories and may contribute to TBI-PTSD comorbidity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.