Evidence map›Paper›PMID 31554863›Full record

ArticleScientific reports2019

Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity.

Nichole Tackett, Jillian H Bradley, Emily K Moore, Stefanie H Baker, Stephanie L Minter, Brian DiGiacinto, Jennifer P Arnold, Randal K Gregg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Microgravity and immune cells.Journal of the Royal Society, Interface · 2023
    Review
  11. Article
  12. Review
  13. Cholesterol: An Important Determinant of Muscle Atrophy in Astronauts.Journal of biotechnology and biomedicine · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Nichole TackettDepartment of Biology, Chemistry and Physics, Converse College, Spartanburg, SC, 29302, USA.
Jillian H BradleyMagnolia Research Center, Division of Biomedical Sciences, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine Carolinas Campus, Spartanburg, SC, 29303, USA.
Emily K MooreDepartment of Biology, Wofford College, Spartanburg, SC, 29303, USA.
Stefanie H BakerDepartment of Biology, Wofford College, Spartanburg, SC, 29303, USA.
Stephanie L MinterMagnolia Research Center, Division of Biomedical Sciences, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine Carolinas Campus, Spartanburg, SC, 29303, USA.
Brian DiGiacintoMagnolia Research Center, Division of Biomedical Sciences, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine Carolinas Campus, Spartanburg, SC, 29303, USA.
Jennifer P ArnoldMagnolia Research Center, Division of Biomedical Sciences, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine Carolinas Campus, Spartanburg, SC, 29303, USA.
Randal K GreggMagnolia Research Center, Division of Biomedical Sciences, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine Carolinas Campus, Spartanburg, SC, 29303, USA. randy.gregg@lmunet.edu.
Edward Via College of Osteopathic Medicine · USWofford College · USConverse College · USLincoln Memorial University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune dysfunction due to microgravity remains a hurdle in the next step of human space exploration. Dendritic cells (DC) represent a critical component of immunity, given their role in the detection of invaders and the subsequent task of activating T cells to respond and eliminate the threat. Upon encounter with microbes, DC undergo a process of maturation, whereby the cells upregulate the expression of surface proteins and secrete cytokines, both required for the optimal activation of CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Culture TechniquesCell LineDendritic CellsHybridomasInterferon-gammaInterleukin-2Interleukin-6MiceModels, AnimalWeightlessness SimulationIFNG protein, mouseInterferon-gammaInterleukin-2Interleukin-6interleukin-6, mouse

Identifiers

PMID31554863
PMCPMC6761163
OpenAlexW2975591693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.