ArticleScientific reports2019
Nonlinear heart rate variability biomarkers for gastric cancer severity: A pilot study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effects of Traditional Chinese Medicine "Fuzheng Qingdu Decoction" on Autonomic Function and Cancer-Related Symptoms in Patients with Advanced Gastric Cancer undergoing Chemotherapy: A Controlled Trial.Integrative cancer therapiesTrial
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- Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults.Journal of the American Heart Association · 2025Article
- Heart rate variability and heart rate asymmetry in adolescents with major depressive disorder during nocturnal sleep period.BMC psychiatry · 2025Article
- Prediction models for lymph node metastasis in cervical cancer based on preoperative heart rate variability.Frontiers in neuroscience · 2024Article
- Heart Rate Asymmetry, Its Compensation, and Heart Rate Variability in Healthy Adults during 48-h Holter ECG Recordings.Journal of clinical medicine · 2023Article
- Heart Rate Asymmetry in Healthy Children.Journal of clinical medicine · 2023Article
- Vagal Nerve Activity Predicts Prognosis in Diffused Large B-Cell Lymphoma and Multiple Myeloma.Journal of clinical medicine · 2023Article
- Association of heartbeat complexity with survival in advanced non-small cell lung cancer patients.Frontiers in neuroscience · 2023Article
- Entropy Analysis of Heart Rate Variability in Different Sleep Stages.Entropy (Basel, Switzerland) · 2022Article
- An assessment of heart rate and blood pressure asymmetry in the diagnosis of vasovagal syncope in females.Frontiers in physiology · 2022Article
- Non-invasive prognostic biomarker of lung cancer patients with brain metastases: Recurrence quantification analysis of heart rate variability.Frontiers in physiology · 2022Article
- Cancer classification using machine learning and HRV analysis: preliminary evidence from a pilot study.Scientific reports · 2021Article
- Association between short-term heart rate variability and blood coagulation in patients with breast cancer.Scientific reports · 2021Article
- Assessment of Epinephrine and Norepinephrine in Gastric Carcinoma.International journal of molecular sciences · 2021Article
- Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men.Frontiers in physiology · 2021Article
- Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer.Cancer management and research · 2021Article
- Association of Short-Term Heart Rate Variability With Breast Tumor Stage.Frontiers in physiology · 2021Article
- Individualized Prediction of Colorectal Cancer Metastasis Using a Radiogenomics Approach.Frontiers in oncology · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying prognostic factors by affordable tools is crucial for guiding gastric cancer (GC) treatments especially at earlier stages for timing interventions. The autonomic function that is clinically assessed by heart rate variability (HRV) is involved in tumorigenesis. This pilot study was aimed to examine whether nonlinear indices of HRV can be biomarkers of GC severity. Sixty-one newly-diagnosed GC patients were enrolled. Presurgical serum fibrinogen (FIB), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA199) were examined. Resting electrocardiogram (ECG) of 5-min was collected prior to surgical treatments to enable the HRV analysis. Twelve nonlinear HRV indices covering the irregularity, complexity, asymmetry, and temporal correlation of heartbeat fluctuations were obtained. Increased short-range temporal correlations, decreased asymmetry, and increased irregularity of heartbeat fluctuations were associated with higher FIB level. Increased irregularity and decreased complexity were also associated with higher CEA level. These associations were independent of age, sex, BMI, alcohol consumption, history of diabetes, left ventricular ejection fraction, and anemia. The results support the hypothesis that perturbations in nonlinear dynamical patterns of HRV predict increased GC severity. Replication in larger samples as well as the examination of longitudinal associations of HRV nonlinear features with cancer prognosis/survival are warranted.
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