Evidence map›Paper›PMID 31554825›Full record

ArticleScientific reports2019

Dual-probe molecular MRI for the in vivo characterization of atherosclerosis in a mouse model: Simultaneous assessment of plaque inflammation and extracellular-matrix remodeling.

Carolin Reimann, Julia Brangsch, Jan O Kaufmann, Lisa C Adams, David C Onthank, Christa Thöne-Reineke, Simon P Robinson, Bernd Hamm, Rene M Botnar, Marcus R Makowski

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Carolin ReimannCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. Carolin.Reimann@charite.de.
Julia BrangschCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Jan O KaufmannCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Lisa C AdamsCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0001-5836-4542
David C OnthankLantheus Medical Imaging, North Billerica, Massachusetts, 331 Treble Cove Road, USA.
Christa Thöne-ReinekeDepartment of Veterinary Medicine, Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Freie Universität Berlin, Königsweg 67, Building 21, 14163, Berlin, Germany.ORCID http://orcid.org/0000-0003-0782-2755
Simon P RobinsonLantheus Medical Imaging, North Billerica, Massachusetts, 331 Treble Cove Road, USA.
Bernd HammCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Rene M BotnarKing's College London, School of Biomedical Engineering and Imaging Sciences, St Thomas' Hospital Westminster Bridge Road, London, SE1 7EH, United Kingdom.ORCID http://orcid.org/0000-0002-9447-4367
Marcus R MakowskiCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Humboldt-Universität zu Berlin · DELantheus Medical Imaging (United States) · USSt Thomas' Hospital · GBAnimal Welfare Institute · USFederal Institute For Materials Research and Testing · DEFreie Universität Berlin · DE

Funding

British Heart Foundation RG/12/1/29262
6 · The paper itself

Abstract

Molecular MRI is a promising in-vivo modality to detect and quantify morphological and molecular vessel-wall changes in atherosclerosis. The combination of different molecular biomarkers may improve the risk stratification of patients. This study aimed to investigate the feasibility of simultaneous visualization and quantification of plaque-burden and inflammatory activity by dual-probe molecular MRI in a mouse-model of progressive atherosclerosis and in response-to-therapy. Homozygous apolipoprotein E knockout mice (ApoE

Indexed as

AnimalsContrast MediaDiet, High-FatDisease Models, AnimalElastinFeasibility StudiesFerrosoferric OxideGadoliniumHydroxymethylglutaryl-CoA Reductase InhibitorsMagnetic Resonance ImagingMaleMiceMice, Knockout, ApoENitric OxidePlaque, AtheroscleroticPravastatinContrast MediaElastinFerrosoferric OxideGadoliniumHydroxymethylglutaryl-CoA Reductase InhibitorsNitric OxidePravastatin

Identifiers

PMID31554825
PMCPMC6761132
OpenAlexW2976008154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.