ArticlemSphere2019
Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?
Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Current Status and Future Challenges in the Use of Bacteriocins to Modulate Ruminant Gut Microbiota.Probiotics and antimicrobial proteins · 2026Review
- Removal of the ionophore antibiotic narasin using vegetal materials as bioadsorbents.RSC advances · 2026Article
- Coccidiosis prevention strategies shape the microbiome, resistome and mobilome composition in the broiler gut.Animal microbiome · 2026Article
- Multi-Detection of Veterinary Medicines in Animal Feed for Production: A Review.Antibiotics (Basel, Switzerland) · 2025Review
- The ionophore resistance genesmSphere · 2025Article
- Article
- Effects of monensin, phytogenic compounds, or a blend of feed additives on health and performance of dairy cows.Translational animal science · 2025Article
- Environmental sustainability and ruminant production: A UK veterinary perspective.The Veterinary record · 2024Review
- Is the Use of Monensin Another Trojan Horse for the Spread of Antimicrobial Resistance?Antibiotics (Basel, Switzerland) · 2024Article
- Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Role of Stakeholders' Understandings in Emerging Antimicrobial Resistance: A One Health Approach.Microorganisms · 2023Review
- Polyether Ionophore Antibiotics Target Drug-Resistant Clinical Isolates, Persister Cells, and Biofilms.Microbiology spectrum · 2023Article
- Cattle-compost-soil: The transfer of antibiotic resistance in livestock agriculture.MicrobiologyOpen · 2023Article
- Eimeria infections in domestic and wild ruminants with reference to control options in domestic ruminants.Parasitology research · 2022Review
- Impact of Dietary Sodium Butyrate and Salinomycin on Performance and Intestinal Microbiota in a Broiler Gut Leakage Model.Animals : an open access journal from MDPI · 2022Article
- Antimicrobial Resistance inMicrobiology spectrum · 2021Article
- Tackling Antibiotic Resistance with Compounds of Natural Origin: A Comprehensive Review.Biomedicines · 2020Review
- Surveillance of Antibiotic Resistance of Maltose-NegativeAntibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Ionophores are the second most widely used class of antibiotic in agriculture, with over 4 million kilograms sold in the United States in 2016. Because ionophores are not used in humans, it is widely assumed that their agricultural use will not impact human health. Consequently, these drugs have not been subject to the same regulations as medically important antibiotics. Here, I argue that the current evidence base is insufficient to conclude that ionophores do not contribute to human relevant antimicrobial resistance. It is unclear whether ionophore resistance can result in cross-resistance to medically important antibiotics. Moreover, recent evidence suggests that ionophore use may coselect for resistance to vancomycin in some cases. Systematic investigation of the consequences of agricultural ionophore use for human health is therefore imperative.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.