Evidence map›Paper›PMID 31554696›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

A Human IgE Antibody Binding Site on Der p 2 for the Design of a Recombinant Allergen for Immunotherapy.

Jill Glesner, A Brenda Kapingidza, Magdalena Godzwon, Lesa R Offermann, Geoffrey A Mueller, Eugene F DeRose, Paul Wright, Crystal M Richardson, Judith A Woodfolk, Lisa D Vailes and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Microscopic Menaces: The Impact of Mites on Human Health.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Role of Small Molecule Ligands in IgE-Mediated Allergy.Current allergy and asthma reports · 2023
    Review
  7. Article
  8. Human Monoclonal IgE Antibodies-a Major Milestone in Allergy.Current allergy and asthma reports · 2023
    Review
  9. Determination of immunogenic epitopes in major house dust mite allergen, Der p 2, via nanoallergens.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Mapping Human Monoclonal IgE Epitopes on the Major Dust Mite Allergen Der p 2.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  16. Article
  17. Nanobodies-Useful Tools for Allergy Treatment?Frontiers in immunology · 2020
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Jill GlesnerIndoor Biotechnologies, Inc., Charlottesville, VA 22903.
A Brenda KapingidzaUniversity of South Carolina, Columbia, SC 29208.ORCID 0000-0001-8517-6299
Magdalena GodzwonLund University, S-22381 Lund, Sweden.
Lesa R OffermannUniversity of South Carolina, Columbia, SC 29208.ORCID 0000-0002-0365-7978
Geoffrey A MuellerNational Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709; and.ORCID 0000-0001-8361-5323
Eugene F DeRoseNational Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709; and.ORCID 0000-0003-0112-1296
Paul WrightUniversity of Virginia, Charlottesville, VA 22903.
Crystal M RichardsonIndoor Biotechnologies, Inc., Charlottesville, VA 22903.
Judith A WoodfolkUniversity of Virginia, Charlottesville, VA 22903.
Lisa D VailesIndoor Biotechnologies, Inc., Charlottesville, VA 22903.
Sabina WünschmannIndoor Biotechnologies, Inc., Charlottesville, VA 22903.
Robert E LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709; and.
Martin D ChapmanIndoor Biotechnologies, Inc., Charlottesville, VA 22903.ORCID 0000-0002-0845-3632
Mats OhlinLund University, S-22381 Lund, Sweden.ORCID 0000-0002-5105-1938
Maksymilian ChruszczUniversity of South Carolina, Columbia, SC 29208.ORCID 0000-0001-7521-5485
Anna PomésIndoor Biotechnologies, Inc., Charlottesville, VA 22903; apomes@inbio.com.ORCID 0000-0002-8729-1829
Indoor Biotechnologies (United States) · USNational Institutes of Health · USUniversity of South Carolina · USLund University · SEUniversity of Virginia · US

Funding

Structural and Functional Characterization of AllergensZIAES102906 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MUELLER, GEOFFREY · 2010 to 2025
$10.0M
Antigenic determinants of asthma-associated allergens for design of immunotherapy.R01AI077653 · NIAID · INDOOR BIOTECHNOLOGIES · PI MARTIN D. CHAPMAN, Maksymilian Chruszcz · 2009 to 2026
$9.5M
Intramural NIH HHS ZIA ES102906NIAID NIH HHS R01 AI077653
6 · The paper itself

Abstract

Der p 2 is one of the most important allergens from the house dust mite

Indexed as

Binding Sites, AntibodyAntibodies, MonoclonalAntigens, DermatophagoidesArthropod ProteinsCrystallography, X-RayDesensitization, ImmunologicEpitopesHumansImmunoglobulin EMagnetic Resonance SpectroscopyMutagenesis, Site-DirectedProtein ConformationRecombinant ProteinsAntibodies, MonoclonalAntigens, DermatophagoidesArthropod ProteinsDermatophagoides pteronyssinus antigen p 2EpitopesImmunoglobulin ERecombinant Proteins

Identifiers

PMID31554696
PMCPMC6810898
OpenAlexW2975906924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.