Evidence map›Paper›PMID 31554695›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Distinct PLZF

Huiming Sheng, Idania Marrero, Igor Maricic, Shaohsuan S Fanchiang, Sai Zhang, Derek B Sant'Angelo, Vipin Kumar

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05827562 (Alterations in CD8αβ and CD8αα T Cell Levels in Patients With Rheumatoid Arthritis), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05827562 unknown statusnot on this mapstarted 2023, after this paper: background citation

Alterations in CD8αβ and CD8αα T Cell Levels in Patients With Rheumatoid Arthritis

TypeobservationalSponsorAssiut UniversityRan2023 to 2025Enrolled60ConditionsRheumatoid ArthritisArmsflow cytometry
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Regulatory T Cell-Based Adoptive Cell Therapy in Autoimmunity.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Article
  4. Characterization of novel CD8Cellular and molecular life sciences : CMLS · 2024
    Article
  5. Pathways and mechanisms of CD4Trends in immunology · 2024
    Review
  6. Frontiers in immunology · 2024
    Article
  7. Article
  8. Article
  9. Heterogeneity of circulating CD4Scientific reports · 2022
    Article
  10. Innate and Innate-like Effector Lymphocytes in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. CD8ααSkin health and disease · 2021
    Article
  15. Preface: Unconventional T Cells in Health and Disease.Critical reviews in immunology · 2021
    Article
  16. Review
  17. Advances in the Study of CD8+ Regulatory T Cells.Critical reviews in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Huiming ShengDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-9382-3687
Idania MarreroDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-5793-706X
Igor MaricicDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.
Shaohsuan S FanchiangDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.
Sai ZhangRutgers University, New Brunswick, NJ 08901.
Derek B Sant'AngeloRutgers University, New Brunswick, NJ 08901.ORCID 0000-0002-5510-9367
Vipin KumarDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093; vckumar@ucsd.edu.ORCID 0000-0002-2838-2472
University of California San Diego · USRutgers, The State University of New Jersey · US

Funding

The function of PLZF in innate T cellsR01AI083988 · NIAID · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI SANT'ANGELO, DEREK B. · 2010 to 2014
$2.2M
Regulatory CD4/CD8 T cells in autoimmune demyelinationR01AI052227 · NIAID · TORREY PINES INST FOR MOLECULAR STUDIES · PI KUMAR, VIPIN · 2003 to 2006
$1.4M
A novel population of PLZF+CD8+ regulatory T cells: phenotype and functionR56AI146071 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMAR, VIPIN · 2020 to 2020
$558k
NIAID NIH HHS R01 AI052227NIAID NIH HHS R01 AI083988NIAID NIH HHS R56 AI146071
6 · The paper itself

Abstract

Hepatic immune system is uniquely challenged to mount a controlled effector response to pathogens while maintaining tolerance to diet and microbial Ags. We have identified a novel population of innate-like, unconventional CD8αα

Indexed as

AnimalsAutoimmunityCD8-Positive T-LymphocytesHealthy VolunteersHumansLiverMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPromyelocytic Leukemia Zinc Finger ProteinPromyelocytic Leukemia Zinc Finger ProteinZBTB16 protein, humanZbtb16 protein, mouse

Identifiers

PMID31554695
PMCPMC6783388
OpenAlexW2975130305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.