SynthesisDeutsches Arzteblatt international2019
Functional Somatic Symptoms.
Synthesis in Deutsches Arzteblatt international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06232473 (Efficacy of Patient Education and Duloxetine, Alone or in Combination, for Patients With Multisystem Functional Somatic Disorder), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Patient Education and Duloxetine, Alone or in Combination, for Patients With Multisystem Functional Somatic Disorder
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of mindfulness- and acceptance-based cognitive-behavioral therapies for bodily distress in adults: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- [Recommendations of the second update of the LONTS guidelines : Long-term opioid therapy for chronic noncancer pain].Schmerz (Berlin, Germany) · 2020Pooled it
- Evaluation of a new body-focused group therapy versus a guided self-help group program for adults with psychogenic non-epileptic seizures (PNES): a pilot randomized controlled feasibility study.Journal of neurology · 2022Trial
- [Rare diseases: a concept for a structured diagnostic pathway].Innere Medizin (Heidelberg, Germany) · 2026Review
- How Were Functional Somatic Symptoms in Children Influenced by the COVID-19 Pandemic? A Retrospective Study of Children Admitted to a Tertiary Pediatric Emergency Hospital in Bucharest, Romania.Life (Basel, Switzerland) · 2026Article
- Frequency and correlates of somatic symptoms in patients of depression: a cross-sectional study at PIMS Islamabad.Annals of medicine and surgery (2012) · 2026Article
- RDoC Mechanisms Underlying Bodily Symptoms in Psychiatry: A Scoping Review.Psychology research and behavior management · 2026Review
- Illness anxiety disorder and somatic symptom disorder: Similarities and differences in health-anxious individuals.PloS one · 2026Article
- Comparative analysis of emotional factors in patients with somatic symptom disorder and panic disorder.Dialogues in clinical neuroscience · 2025Article
- Functional/dissociative seizures: Proposal for a new diagnostic label and definition by the ILAE task force.Epilepsia · 2025Article
- [Comorbidity of chronic pain and fatigue : Common mechanisms, common treatment steps?]Schmerz (Berlin, Germany) · 2025Review
- Review article: Somatization Disorders in emergency department: A critical overview of current challenges and future directions.Emergency medicine Australasia : EMA · 2025Review
- The overlooked burden of persistent physical symptoms: a call for action in European healthcare.The Lancet regional health. Europe · 2025Review
- Functional somatic symptoms in Emergency Department frequent presenters.BMC emergency medicine · 2024Article
- Exploring the course of functional somatic symptoms (FSS) from pre- to late adolescence and associated internalizing psychopathology - an observational cohort-study.BMC psychiatry · 2024Observational
- [Transdisciplinary treatment of functional movement disorders: integration instead of dissociation].Der Nervenarzt · 2024Article
- The burden of persistent symptom diagnoses in primary care patients: a cross-sectional study.Scandinavian journal of primary health care · 2024Article
- Acquiring a new understanding of illness and agency: a narrative study of recovering from chronic fatigue syndrome.International journal of qualitative studies on health and well-being · 2023Article
- Psychological flexibility and global health in young adults with and without a self-reported functional somatic syndrome: a preliminary investigation.Psychology, health & medicine · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 10% of the general population and around one third of adult patients in clinical populations suffer from functional somatic symptoms. These take many forms, are often chronic, impair everyday functioning as well as quality of life, and are cost intensive.
methodsThe guideline group (32 medical and psychological professional societies, two patients' associations) carried out a systematic survey of the literature and ana- lyzed 3795 original articles and 3345 reviews. The aim was to formulate empirically based recommendations that were practical and user friendly.
resultsBecause of the variation in course and symptom severity, three stages of treatment are distinguished. In early contacts, the focus is on basic investigations, reassurance, and advice. For persistent burdensome symptoms, an extended, simultaneous and equitable diagnostic work-up of physical and psychosocial factors is recommended, together with a focus on information and self-help. In the pres- ence of severe and disabling symptoms, multimodal treatment includes further elements such as (body) psychotherapeutic and social medicine measures. Whatever the medical specialty, level of care, or clinical picture, an empathetic professional attitude, reflective communication, information, a cautious, restrained approach to diagnosis, good interdisciplinary cooperation, and above all active interventions for self-efficacy are usually more effective than passive, organ- focused treatments.
conclusionThe cornerstones of diagnosis and treatment are biopsychosocial ex- planatory models, communication, self-efficacy, and interdisciplinary mangagement. This enables safe and efficient patient care from the initial presentation onwards, even in cases where the symptoms cannot yet be traced back to specific causes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.