Evidence map›Paper›PMID 31554245›Full record

ArticleInternational journal of molecular sciences2019

The Antioxidant and Antiproliferative Activities of 1,2,3-Triazolyl-L-Ascorbic Acid Derivatives.

Anja Harej, Andrijana Meščić Macan, Višnja Stepanić, Marko Klobučar, Krešimir Pavelić, Sandra Kraljević Pavelić, Silvana Raić-Malić

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Micronutrient Status and Breast Cancer: A Narrative Review.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Application of triazoles in the structural modification of natural products.Journal of enzyme inhibition and medicinal chemistry · 2021
    Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Anja HarejCentre for High-throughput Technologies, Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, 51000 Rijeka, Croatia. aharej@biotech.uniri.hr.
Andrijana Meščić MacanDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, 10000 Zagreb, Croatia. amescic@fkit.hr.ORCID 0000-0002-0537-0292
Višnja StepanićDivision of Electronics, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. Visnja.Stepanic@irb.hr.ORCID 0000-0001-9518-4153
Marko KlobučarCentre for High-throughput Technologies, Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, 51000 Rijeka, Croatia. mklobucar@biotech.uniri.hr.
Krešimir PavelićFaculty of medicine, Juraj Dobrila University of Pula, Zagrebačka 30, 52100 Pula, Croatia. kresimir.pavelic@unipu.hr.
Sandra Kraljević PavelićCentre for High-throughput Technologies, Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, 51000 Rijeka, Croatia. sandrakp@biotech.uniri.hr.ORCID 0000-0003-0491-673X
Silvana Raić-MalićDepartment of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, 10000 Zagreb, Croatia. sraic@fkit.hr.ORCID 0000-0001-5021-8970
University of Rijeka · HRUniversity of Zagreb · HRJuraj Dobrila University of Pula · HRRuđer Bošković Institute · HR

Funding

European Regional Development Fund-the Competitiveness and Cohesion Operational Programme - KK.01.1.1.01 KK.01.1.1.01.0002Hrvatska Zaklada za Znanost HRZZ-IP-2018-01-4682University of Rijeka research support uniri-biomed-18-133
6 · The paper itself

Abstract

The novel 4-substituted 1,2,3-triazole L-ascorbic acid (L-ASA) conjugates with hydroxyethylene spacer as well as their conformationally restricted 4,5-unsaturated analogues were synthesized as potential antioxidant and antiproliferative agents. An evaluation of the antioxidant activity of novel compounds showed that the majority of the 4,5-unsaturated L-ASA derivatives showed a better antioxidant activity compared to their saturated counterparts.

Indexed as

Antineoplastic AgentsAntioxidantsAscorbic AcidCell ProliferationDose-Response Relationship, DrugHumansMCF-7 CellsMitochondriaMolecular StructureQuantum TheoryAntineoplastic AgentsAntioxidantsAscorbic Acid1,2,3-triazoleantioxidantantitumorHIF-1quantum-chemical modellingvitamin C

Identifiers

PMID31554245
PMCPMC6801448
OpenAlexW2977131896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.