Evidence map›Paper›PMID 31554217›Full record

ArticleNutrients2019

Chemosensory Changes from Cancer Treatment and Their Effects on Patients' Food Behavior: A Scoping Review.

Alissa A Nolden, Liang-Dar Hwang, Anna Boltong, Danielle R Reed

Registry-linked trialAbstract readScoping Review
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07317752 (Incidenza Della Disgeusia Nei Pazienti Affetti da Carcinoma Mammario in Trattamento Chemioterapico), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07317752 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Incidenza Della Disgeusia Nei Pazienti Affetti da Carcinoma Mammario in Trattamento Chemioterapico: Uno Studio Pilota Prospettico

TypeobservationalSponsorAzienda Sanitaria Locale CN2 Alba-BraRan2026 to 2027Enrolled40ConditionsTaste Disorders, Breast Cancer, Quality of Life, Taste PerceptionArmsTaste Assessment / Nutritional Assessment / Quality of Life Assessment
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Personality traits are associated with the development and severity of chemosensory alterations during chemotherapy: a longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Progressive deterioration in dietary intake and nutritional risk during oncological treatment in children with solid tumors: a prospective longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  5. Article
  6. Education Is Treatment: Integrating Chemosensory Dysfunction Education in Oncology Care.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
    Article
  7. Life satisfaction among cancer survivors with and without smell and taste dysfunction: evidence from the National Health Interview Survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  8. Dynamic Network Analysis of Symptom Profiles and Their Expected Impact on Patients with Colorectal Cancer Receiving Postoperative Adjuvant Chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Psychological experience of discharge readiness in head and neck cancer patients undergoing particle radiotherapy: A qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  13. Article
  14. Developing and regenerating a sense of taste.Current topics in developmental biology · 2025
    Review
  15. Article
  16. Taste and Smell Alterations (TSAs) in Cancer Patients.Diseases (Basel, Switzerland) · 2024
    Review
  17. Article
  18. Investigating oral somatosensory perception and oral symptoms of head and neck cancer patients: insights on eating behaviour.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alissa A NoldenFood Science Department, College of Natural Sciences, University of Massachusetts, Amherst, MA 01003, USA. anolden@umass.edu.ORCID 0000-0001-9525-5580
Liang-Dar HwangThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland 4102, Australia. danielldhwang@gmail.com.ORCID 0000-0002-5535-2199
Anna BoltongVictorian Comprehensive Cancer Centre, Melbourne 3000, Australia. anna.boltong@unimelb.edu.au.
Danielle R ReedMonell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. reed@monell.org.ORCID 0000-0002-4374-6107

Funding

INTERDISCIPLINARY TRAINING IN THE CHEMICAL SENSEST32DC000014 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI PAMELA HELEN DALTON, Joel D Mainland · 1989 to 2026
$6.2M
NIDCD NIH HHS T32 DC000014NIH National Research Service Award T32 Fellowship DC000014
6 · The paper itself

Abstract

Individuals undergoing treatment for cancer can experience changes in taste or smell that are often assumed to affect constructs related to food behavior, although this relationship is rarely measured directly. To ascertain the extent to which measured changes in taste and smell during and after cancer treatment affect food behavior, we conducted a scoping review and completed a comparative analysis for studies that met our criteria, which were: they directly measured cancer patients' (a) psychophysical response to taste and/or olfactory stimuli, and (b) food behavior (including food enjoyment, food preference, dietary intake) in people affected by cancer. Eleven studies met these criteria and were included in the review. All 11 studies evaluated taste and five also measured smell. A comparative analysis exploring taste and food behavior shows that a reduced sweet taste function (decreased sensitivity) was associated with a reduced intake of a variety of different macro and micro nutrients, reduced appetite, and overall lower energy intake. One out of six studies that measured smell and food measured observed changes in olfactory function following cancer treatment. There were no significant relationships reported between olfactory measures and food behavior. Taste changes that arise from cancer treatment appear to have a direct effect on food behavior, although there is a need for more research using standardized measures and larger sample sizes. A better understanding of taste alterations and their implications for dietary intake and food enjoyment will support optimal nutritional health by identifying strategies to help patients eat well during and after cancer treatment.

Indexed as

Antineoplastic AgentsFeeding BehaviorHumansNeoplasmsSmellTasteAntineoplastic Agentsappetitechemosensory dysfunctionchemosensory losschemosensory perceptionchemotherapydieticiandysgeusiaflavoroncologysmelltaste

Identifiers

PMID31554217
PMCPMC6836020

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.