ArticleAmerican journal of nephrology2019
Associations of Urine Biomarkers with Kidney Function Decline in HIV-Infected and Uninfected Men.
Article in American journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 19 citations in OpenAlex.
- Coagulation is associated with renal function decline and chronic kidney disease in people living with HIV in South Africa.Frontiers in nephrology · 2026Article
- Evolution of kidney function after five years of follow-up in a large Spanish cohort of patients with HIV: risk factors for progression.BMC infectious diseases · 2025Observational
- The relationship between kidney function and the soluble (pro)renin receptor in young adults: the African-PREDICT study.BMC nephrology · 2025Article
- Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies.Kidney medicine · 2024Article
- Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV.BMC nephrology · 2021Article
- Kidney tubule health scores and their associations with incident CKD in women living with HIV.HIV medicine · 2021Article
- Urine Alpha-1-Microglobulin Levels and Acute Kidney Injury, Mortality, and Cardiovascular Events following Cardiac Surgery.American journal of nephrology · 2021Article
- The utility of kidney injury molecule-1 as an early biomarker of kidney injury in people living with HIV.International journal of STD & AIDS · 2020Article
- Elevated cardiac risk score by Atherosclerotic Cardiovascular Disease calculation is associated with albuminuria in older people living with HIV.AIDS (London, England) · 2020Article
- HIV preexposure prophylaxis with tenofovir disoproxil fumarate/emtricitabine and changes in kidney function and tubular health.AIDS (London, England) · 2020Article
- Management of Presumed Acute Kidney Injury during Hypertensive Therapy: Stay Calm and Carry on?American journal of nephrology · 2020Review
- Urine Biomarkers of Kidney Tubule Health and Incident CKD Stage 3 in Women Living With HIV: A Repeated Measures Study.Kidney medicineArticle
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Authors and funding
12 authors at 7 institutions in 1 country.
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Abstract
backgroundHIV-infected (HIV+) persons are at increased risk of chronic kidney disease, but serum creatinine does not detect early losses in kidney function. We hypothesized that urine biomarkers of kidney damage would be associated with subsequent changes in kidney function in a contemporary cohort of HIV+ and HIV-uninfected (HIV-) men.
methodsIn the Multicenter AIDS Cohort Study, we measured baseline urine concentrations of 5 biomarkers from 2009 to 2011 in 860 HIV+ and 337 HIV- men: albumin, alpha-1-microglobulin (α1m), interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), and procollagen type III N-terminal propeptide (PIIINP). We evaluated associations of urine biomarker concentrations with annual changes in estimated glomerular filtration rate (eGFR) using multivariable linear mixed models adjusted for demographics, traditional kidney disease risk factors, HIV-related risk factors, and baseline eGFR.
resultsOver a median follow-up of 4.8 years, the average annual eGFR decline was 1.42 mL/min/1.73 m2/year in HIV+ men and 1.22 mL/min/1.73 m2/year in HIV- men. Among HIV+ men, the highest vs. lowest tertiles of albumin (-1.78 mL/min/1.73 m2/year, 95% CI -3.47 to -0.09) and α1m (-2.43 mL/min/1.73 m2/year, 95% CI -4.14 to -0.73) were each associated with faster annual eGFR declines after multivariable adjustment. Among HIV- men, the highest vs. lowest tertile of α1m (-2.49 mL/min/1.73 m2/year, 95% CI -4.48 to -0.50) was independently associated with faster annual eGFR decline. Urine IL-18, KIM-1, and PIIINP showed no independent associations with eGFR decline, regardless of HIV serostatus.
conclusionsAmong HIV+ men, higher urine albumin and α1m are associated with subsequent declines in kidney function, independent of eGFR.
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