Evidence map›Paper›PMID 31553906›Full record

ArticleCell reports2019

Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity.

Lucien P Garo, Amrendra K Ajay, Mai Fujiwara, Vanessa Beynon, Chantal Kuhn, Galina Gabriely, Supriya Sadhukan, Radhika Raheja, Stephen Rubino, Howard L Weiner and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. EngineeredActa pharmaceutica Sinica. B · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lucien P GaroAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Amrendra K AjayRenal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mai FujiwaraAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Vanessa BeynonAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Chantal KuhnAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Galina GabrielyAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Supriya SadhukanAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Radhika RahejaAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Stephen RubinoAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Howard L WeinerAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Gopal MurugaiyanAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: mgopal@rics.bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

MICRORNA CONTROL OF INFLAMMATORY AND REGULATORY T CELLS IN CENTRAL NERVOUS SYSTEM AUTOIMMUNITYR01AI127853 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOPAL, MURUGAIYAN · 2017 to 2021
$2.2M
The pathogenic role of miR-92a in the regulation of T helper cell responses in EAE and MSR01AI151953 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOPAL, MURUGAIYAN · 2020 to 2024
$2.1M
MicroRNA control of tumor-promoting inflammation in colon cancerR01CA267479 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Murugaiyan Gopal · 2022 to 2026
$1.9M
Therapeutic targeting of PD1 signaling in inflammatory bowel diseaseR21AI175890 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOPAL, MURUGAIYAN · 2023 to 2024
$467k
Development of novel PD1 agonist therapeutic strategies for multiple sclerosisR21AI174047 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOPAL, MURUGAIYAN · 2023 to 2024
$442k
NCI NIH HHS R01 CA267479NIAID NIH HHS R01 AI127853NIAID NIH HHS R01 AI151953NIAID NIH HHS R21 AI174047NIAID NIH HHS R21 AI175890
6 · The paper itself

Abstract

Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis and treatment of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC). Here, we found that Smad7 mediates intestinal inflammation by limiting the PDL2/1-PD1 axis in dendritic cells (DCs) and CD4

Indexed as

AutoimmunityHumansInflammationIntestinesSignal TransductionSmad7 ProteinSmad7 ProteinSMAD7 protein, humanCD103DCdendritic cellIBDinflammatory bowel diseasePD1PDL1PDL2Smad7TGF-βTregUCulcerative colitis

Identifiers

PMID31553906
PMCPMC6925592
OpenAlexW2976913461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.