ArticleHepatology (Baltimore, Md.)2020
Hyperpolarized Metabolic Imaging Detects Latent Hepatocellular Carcinoma Domains Surviving Locoregional Therapy.
Article in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Hyperpolarized MRI in Oncology-A Review of Clinical Studies and Evaluation of Preclinical Liver Studies.NMR in biomedicine · 2026Review
- Proof-of-Concept Study of Hyperpolarized [1-Radiology. Imaging cancer · 2026Article
- Hyperpolarized MRI Detects Increased [1-NMR in biomedicine · 2026Article
- Locoregional lactate dehydrogenase inhibition potentiates therapy and overcomes treatment resistance in hepatocellular carcinoma.Hepatology (Baltimore, Md.) · 2026Article
- Magnetic resonance coil prototyping and implementation for multi-nuclear small animal imaging.Journal of magnetic resonance open · 2025Article
- Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025Article
- HyperpolarizedMagnetic resonance in medicine · 2024Article
- Characterizing Metabolic Heterogeneity of Hepatocellular Carcinoma with HyperpolarizedRadiology. Imaging cancer · 2024Article
- Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-Metabolites · 2023Review
- Neurons require glucose uptake and glycolysis in vivo.Cell reports · 2023Article
- Hyperpolarized carbon 13 MRI in liver diseases: Recent advances and future opportunities.Liver international : official journal of the International Association for the Study of the Liver · 2022Review
- Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy.Metabolites · 2021Review
- Current Trends in Non-Invasive Imaging of Interactions in the Liver Tumor Microenvironment Mediated by Tumor Metabolism.Cancers · 2021Review
- Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance.International journal of molecular sciences · 2021Review
- Elastin-specific MRI of extracellular matrix-remodelling following hepatic radiofrequency-ablation in a VX2 liver tumor model.Scientific reports · 2021Article
- Altered copper homeostasis underlies sensitivity of hepatocellular carcinoma to copper chelation.Metallomics : integrated biometal science · 2020Article
- Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
BACKGROUND AND
aimsAdvances in cancer treatment have improved survival; however, local recurrence and metastatic disease-the principal causes of cancer mortality-have limited the ability to achieve durable remissions. Local recurrences arise from latent tumor cells that survive therapy and are often not detectable by conventional clinical imaging techniques. Local recurrence after transarterial embolization (TAE) of hepatocellular carcinoma (HCC) provides a compelling clinical correlate of this phenomenon. In response to TAE-induced ischemia, HCC cells adapt their growth program to effect a latent phenotype that precedes local recurrence. APPROACH AND
resultsIn this study, we characterized and leveraged the metabolic reprogramming demonstrated by latent HCC cells in response to TAE-induced ischemia to enable their detection in vivo using dynamic nuclear polarization (DNP) magnetic resonance spectroscopic imaging (MRSI) of
conclusionsThese studies provide a paradigm for imaging latent, treatment-refractory cancer cells, suggesting that DNP-MRSI provides a technology for this application.
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