Evidence map›Paper›PMID 31553803›Full record

ArticleHepatology (Baltimore, Md.)2020

Diet Associations With Nonalcoholic Fatty Liver Disease in an Ethnically Diverse Population: The Multiethnic Cohort.

Mazen Noureddin, Shira Zelber-Sagi, Lynne R Wilkens, Jacqueline Porcel, Carol J Boushey, Loïc Le Marchand, Hugo R Rosen, Veronica Wendy Setiawan

Abstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Guideline
  6. Pooled it
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  9. Article
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  11. Processing Status, Rather Than Meat Source, Is Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease Among US Adults.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Article
  12. Review
  13. Prediagnostic Plasma Metabolite Profiles and Prediction of Hepatocellular Carcinoma Risk: The Multiethnic Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  14. Socioeconomic Factors and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
  15. Article
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  19. Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mazen NoureddinDivision of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Shira Zelber-SagiSchool of Public Health, University of Haifa, Haifa, Israel.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.
Jacqueline PorcelDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA.
Carol J BousheyEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.
Loïc Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.
Hugo R RosenDepartment of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA.
Veronica Wendy SetiawanDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA.ORCID 0000-0001-9239-5692

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Understanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3M
Understanding the Determinants of Racial/Ethnic Disparities in Liver Cancer and Chronic Liver Disease in Understudied and High-Risk PopulationsR01CA228589 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SETIAWAN, VERONICA WENDY · 2018 to 2021
$1.8M
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA228589NCI NIH HHS R01CA228589NCI NIH HHS U01 CA164973NCI NIH HHS U01CA164973NCI NIH HHS UM1 CA164973
6 · The paper itself

Abstract

BACKGROUND AND

aimsEpidemiological data on dietary risk factors for nonalcoholic fatty liver disease (NAFLD) from population-based studies, particularly in an ethnically diverse population, are scarce. We examined dietary factors in relation to NAFLD risk in African Americans, Japanese Americans, Latinos, native Hawaiians, and whites in the Multiethnic Cohort (MEC). APPROACH AND

resultsA nested case-control analysis was conducted within the MEC, a large prospective study with >215,000 older adult participants in Hawaii and California. NAFLD was identified using Medicare claims data, and controls were selected among participants without liver disease and individually matched to cases by birth year, sex, ethnicity, and length of Medicare enrollment. Diet was assessed at baseline through a validated quantitative food frequency questionnaire. Diet-NAFLD associations were quantified by odds ratios and 95% confidence intervals using multivariable conditional logistic regression. The study consisted of 2,974 NAFLD cases (518 with cirrhosis, 2,456 without cirrhosis) and 29,474 matched controls. Red meat (P trend = 0.010), processed red meat (P trend = 0.004), poultry (P trend = 0.005), and cholesterol (P trend = 0.005) intakes were positively associated with NAFLD, while dietary fiber intake (P trend = 0.003) was inversely associated with risk. Stronger associations were observed between red meat and cholesterol and NAFLD with cirrhosis than without cirrhosis (P heterogeneity ≤0.014).

conclusionsDietary factors are independently associated with NAFLD and NAFLD-related cirrhosis in a multiethnic population. Decreasing the consumption of cholesterol, red and processed meat, and poultry and increasing consumption of fiber may reduce the risk for NAFLD and related advanced liver disease.

Indexed as

DietLiver CirrhosisNon-alcoholic Fatty Liver DiseaseRisk AssessmentCholesterol, DietaryCohort StudiesCorrelation of DataDietary FiberEthnicityFemaleFood PreferencesHumansMaleMedicareMiddle AgedRed MeatCholesterol, DietaryDietary Fiber

Identifiers

PMID31553803
PMCPMC7093243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.