ArticlePloS one2019
Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Neutrophil-to-lymphocyte ratio for the clinical management of dengue: a systematic review and meta-analysis.Frontiers in epidemiology · 2026Pooled it
- Electronic and electrochemical viral detection for point-of-care use: A systematic review.PloS one · 2021Pooled it
- Dengue Fever Diagnosis: Performance Characteristics of Current Tests and Emerging Detection Technologies.Molecular diagnosis & therapy · 2026Review
- Structure guided design and molecular modelling of a novel peptide-SWCNT biosensor targeting NS1 dengue virus.RSC advances · 2025Article
- Advances in Nanobiosensors for Rapid and Sensitive Detection of Dengue Virus Biomarkers by Using Clinical Laboratory.Journal of clinical laboratory analysis · 2025Review
- One-Dimensional HKUST-1-Decorated Glassy Carbon Electrode for the Sensitive Electrochemical Immunosensor of NS1 Dengue Virus Serotype-3.ACS omega · 2024Article
- Label-free and label-based electrochemical detection of disease biomarker proteins.ADMET & DMPK · 2024Review
- Highly Specific Detection of Oxytocin in Saliva.International journal of molecular sciences · 2023Article
- A novel biosensor for ultrasensitive detection of fungal genes.Biosensors & bioelectronics · 2023Article
- Peptide-based direct electrochemical detection of receptor binding domains of SARS-CoV-2 spike protein in pristine samples.Sensors and actuators. B, Chemical · 2023Article
- Rapid electrochemical immunodetection of SARS-CoV-2 using a pseudo-typed vesicular stomatitis virus model.Talanta · 2022Article
- Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems.Biosensors · 2022Review
- Design and Analysis of a Single System of Impedimetric Biosensors for the Detection of Mosquito-Borne Viruses.Biosensors · 2021Article
- The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics.Biosensors · 2021Review
- Dengue Detection: Advances in Diagnostic Tools from Conventional Technology to Point of Care.Biosensors · 2021Review
- Biosensing strategies for the electrochemical detection of viruses and viral diseases - A review.Analytica chimica acta · 2021Review
- Portable Sensing Devices for Detection of COVID-19: A Review.IEEE sensors journal · 2021Article
- Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases.Biosensors & bioelectronics · 2021Review
- Label-Free Electrochemical Biosensors for the Determination ofSensors (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV) nonstructural 1 (NS1) protein is a specific and sensitive biomarker for the diagnosis of dengue. In this study, an efficient electrochemical biosensor that uses chemically modified affinity peptides was developed for the detection of dengue virus NS1. A series of amino acid-substituted synthetic peptides was rationally designed, chemically synthesized and covalently immobilized to a gold sensor surface. The sensor performance was monitored via square wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS). Potential affinity peptides specific for NS1 were chosen according to the dynamic current decrease in SWV experiments. Using circular dichroism, the molar ellipticity of peptides (DGV BP1-BP5) was determined, indicating that they had a mostly similar in random coil structure, not totally identical. Using SWV, DGV BP1 was selected as a promising recognition peptide and limit of detection for NS1 was found to be 1.49 μg/mL by the 3-sigma rule. DGV BP1 showed good specificity and stability for NS1, with low signal interference. The validation of the sensor to detect NS1 proteins was confirmed with four dengue virus culture broth (from serotype 1 to 4) as proof-of-concept. The detection performance of our sensor incorporating DGV BP1 peptides showed a statistically significant difference. These results indicate that this strategy can potentially be used to detect the dengue virus antigen, NS1, and to diagnosis dengue fever within a miniaturized portable device in point-of-care testing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.