ArticlePLoS genetics2019
Evolution of the Auxin Response Factors from charophyte ancestors.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- AUXIN RESPONSE FACTORs: from transcription factors to auxin effectors.The New phytologist · 2026Review
- The Arabidopsis ARF3-AIP1/2-SAP18 module specifies the root stem cell niche in response to auxin.The Plant cell · 2026Article
- Mechanisms driving functional divergence of transcription factor paralogs.The New phytologist · 2025Review
- Shikimate Kinase-Like 1 Participates in an Ancient and Conserved Role Contributing to Chloroplast Biogenesis in Land Plants.Molecular biology and evolution · 2025Article
- Auxin and tryptophan trigger common responses in the streptophyte alga Penium margaritaceum.Current biology : CB · 2025Article
- A conserved ARF-DNA interface underlies auxin-triggered transcriptional response.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Origin and evolution of auxin-mediated acid growth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evolution of plant metabolism: the state-of-the-art.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Phylogeny and evolution of streptophyte algae.Annals of botany · 2024Review
- Evolutionary assembly of the plant terrestrialization toolkit from protein domains.Proceedings. Biological sciences · 2024Article
- Genomic survey and expression analysis of LcARFs reveal multiple functions to somatic embryogenesis in Liriodendron.BMC plant biology · 2024Article
- Evolution and function analysis of auxin response factors reveal the molecular basis of the developed root system of Zygophyllum xanthoxylum.BMC plant biology · 2024Review
- Game of thrones among AUXIN RESPONSE FACTORs-over 30 years of MONOPTEROS research.Journal of experimental botany · 2023Review
- To bind or not to bind: how AUXIN RESPONSE FACTORs select their target genes.Journal of experimental botany · 2023Review
- AUXIN RESPONSE FACTOR protein accumulation and function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- Cis-regulatory elements and transcription factors related to auxin signaling in the streptophyte algae Klebsormidium nitens.Scientific reports · 2023Article
- The birth of a giant: evolutionary insights into the origin of auxin responses in plants.The EMBO journal · 2023Review
- The cell biology of charophytes: Exploring the past and models for the future.Plant physiology · 2022Article
- TOPLESS in the regulation of plant immunity.Plant molecular biology · 2022Review
- Does integument ariseFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin is a major developmental regulator in plants and the acquisition of a transcriptional response to auxin likely contributed to developmental innovations at the time of water-to-land transition. Auxin Response Factors (ARFs) Transcription Factors (TFs) that mediate auxin-dependent transcriptional changes are divided into A, B and C evolutive classes in land plants. The origin and nature of the first ARF proteins in algae is still debated. Here, we identify the most 'ancient' ARF homologue to date in the early divergent charophyte algae Chlorokybus atmophyticus, CaARF. Structural modelling combined with biochemical studies showed that CaARF already shares many features with modern ARFs: it is capable of oligomerization, interacts with the TOPLESS co-repressor and specifically binds Auxin Response Elements as dimer. In addition, CaARF possesses a DNA-binding specificity that differs from class A and B ARFs and that was maintained in class C ARF along plants evolution. Phylogenetic evidence together with CaARF biochemical properties indicate that the different classes of ARFs likely arose from an ancestral proto-ARF protein with class C-like features. The foundation of auxin signalling would have thus happened from a pre-existing hormone-independent transcriptional regulation together with the emergence of a functional hormone perception complex.
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