Evidence map›Paper›PMID 31553512›Full record

ReviewChembiochem : a European journal of chemical biology2020

Small-Molecule Inhibition of Glucose Transporters GLUT-1-4.

Elena S Reckzeh, Herbert Waldmann

Open access · hybridAbstract readReview
In one paragraph

Review in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 99 citations in OpenAlex.

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  15. A prospective study to compare the diagnostic accuracy ofJournal of cancer research and clinical oncology · 2024
    Article
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  17. Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elena S ReckzehDepartment Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Herbert WaldmannDepartment Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.ORCID 0000-0002-9606-7247
TU Dortmund University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucose addiction is observed in cancer and other diseases that are associated with hyperproliferation. The development of compounds that restrict glucose supply and decrease glycolysis has great potential for the development of new therapeutic approaches. Addressing facilitative glucose transporters (GLUTs), which are often upregulated in glucose-dependent cells, is therefore of particular interest. This article reviews a selection of potent, isoform-selective GLUT inhibitors and their biological characterization. Potential therapeutic applications of GLUT inhibitors in oncology and other diseases that are linked to glucose addiction are discussed.

Indexed as

GlucoseGlucose Transporter Type 1Glucose Transporter Type 2Glucose Transporter Type 3Glucose Transporter Type 4HumansModels, MolecularMolecular StructureSmall Molecule LibrariesGlucoseGlucose Transporter Type 1Glucose Transporter Type 2Glucose Transporter Type 3Glucose Transporter Type 4SLC2A1 protein, humanSLC2A2 protein, humanSLC2A3 protein, humanSLC2A4 protein, humanSmall Molecule Librariesantitumor agentscancerdrug discoveryGLUT inhibitorsmetabolism

Identifiers

PMID31553512
PMCPMC7004114
OpenAlexW2975656210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.