ArticleSleep2020
Selective activation of serotoninergic dorsal raphe neurons facilitates sleep through anxiolysis.
Article in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.Journal of evidence-based integrative medicinePooled it
- Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats.Psychopharmacology · 2026Article
- Article
- Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state.eLife · 2026Article
- Bioactive Peptides from Yellowfin Tuna By-Products: Structural Characterization and Neuro-Related Activities in PC12 Cells.Current issues in molecular biology · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Age-Associated Development of Sleep Disturbances inNature and science of sleep · 2026Article
- Insomnia Pathogenesis and Multidimensional Mechanisms of Acupuncture: A Narrative Review.International journal of general medicine · 2026Review
- IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications.Brain, behavior, & immunity - health · 2025Review
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.bioRxiv : the preprint server for biology · 2025Article
- ParabrachialiScience · 2025Article
- Serotonin neurons are necessary for tonic sodium intake inhibition.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Spatial differences in gene expression across the dorsal raphe nucleus in a model of early Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- Article
- Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer's disease.Pharmacological research · 2024Review
- Serotonergic modulation of vigilance states in zebrafish and mice.Nature communications · 2024Article
- Medial and lateral vestibulospinal projections to the cervical spinal cord of the squirrel monkey.Frontiers in neurology · 2024Article
- Neural Control of REM Sleep and Motor Atonia: Current Perspectives.Current neurology and neuroscience reports · 2023Review
- Sedative-Hypnotic Effects ofInternational journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A role for the brain's serotoninergic (5HT) system in the regulation of sleep and wakefulness has been long suggested. Yet, previous studies employing pharmacological, lesion and genetically driven approaches have produced inconsistent findings, leaving 5HT's role in sleep-wake regulation incompletely understood. Here we sought to define the specific contribution of 5HT neurons within the dorsal raphe nucleus (DRN5HT) to sleep and arousal control. To do this, we employed a chemogenetic strategy to selectively and acutely activate DRN5HT neurons and monitored sleep-wake using electroencephalogram recordings. We additionally assessed indices of anxiety using the open field and elevated plus maze behavioral tests and employed telemetric-based recordings to test effects of acute DRN5HT activation on body temperature and locomotor activity. Our findings indicate that the DRN5HT cell population may not modulate sleep-wake per se, but rather that its activation has apparent anxiolytic properties, suggesting the more nuanced view that DRN5HT neurons are sleep permissive under circumstances that produce anxiety or stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.