ArticleMemorias do Instituto Oswaldo Cruz2019
Liaisons dangereuses: cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guiana.
Article in Memorias do Instituto Oswaldo Cruz, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Interactions between mosquito genetic background and Wolbachia strain affect dengue virus blocking and fitness in South American populations of Aedes aegypti.PLoS neglected tropical diseases · 2026Article
- Evidence of insecticide resistance in Aedes aegypti populations of Suriname: first report of malathion resistance and presence of the kdr mutations V410L, V1016I and F1534C.Memorias do Instituto Oswaldo Cruz · 2026Article
- Genetic structure and kdr mutations in Aedes aegypti populations along a road crossing the Amazon Forest in Amapá State, Brazil.Scientific reports · 2023Article
- Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China.Parasites & vectors · 2022Article
- Genome-wide Association Study Reveals New Loci Associated With Pyrethroid Resistance inFrontiers in genetics · 2022Article
- High larvicidal efficacy of yeast-encapsulated orange oil against Aedes aegypti strains from Brazil.Parasites & vectors · 2021Article
- Two Haplotypes ofInsects · 2021Article
- Differential attraction in mosquito-human interactions and implications for disease control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control.Memorias do Instituto Oswaldo Cruz · 2021Article
- Vector Competence ofPathogens (Basel, Switzerland) · 2020Article
- Tracing temporal and geographic distribution of resistance to pyrethroids in the arboviral vector Aedes albopictus.PLoS neglected tropical diseases · 2020Article
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9 authors.
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Abstract
backgroundIn recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission.
objectivesIn order to improve vector control it is essential to study mosquito population genetics in order to better estimate the population structures and the geneflow among them.
methodsWe have analysed microsatellites and knockdown resistance (kdr) mutations from a trans-border region in Amazonia between the state of Amapá (Brazil) and French Guiana (overseas territory of France), to provide further knowledge on these issues. These two countries have followed distinct vector control policies since last century. For population genetic analyses we evaluated variability in 13 well-established microsatellites loci in Ae. aegypti from French Guiana (Saint Georges and Cayenne) and Brazil (Oiapoque and Macapá). The occurrence and frequency of kdr mutations in these same populations were accessed by TaqMan genotype assays for the sites 1016 (Val/Ile) and 1534 (Phe/Cys).
findingsWe have detected high levels of gene flow between the closest cross-border samples of Saint-Georges and Oiapoque. These results suggest one common origin of re-colonisation for the populations of French Guiana and Oiapoque in Brazil, and a different source for Macapá, more similar to the other northern Brazilian populations. Genotyping of the kdr mutations revealed distinct patterns for Cayenne and Macapá associated with their different insecticide use history, and an admixture zone between these two patterns in Saint Georges and Oiapoque, in accordance with population genetic results. MAIN
conclusionsThe present study highlights the need for regional-local vector surveillance and transnational collaboration between neighboring countries to assess the impact of implemented vector control strategies, promote timely actions and develop preparedness plans.
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