ArticleCell proliferation2019
Regenerative potential of human dental pulp stem cells in the treatment of stress urinary incontinence: In vitro and in vivo study.
Article in Cell proliferation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies.International journal of molecular sciences · 2022Pooled it
- Mesenchymal stem Cells and Extracellular Vesicles in Bladder Dysfunction: Mechanisms and Translational Perspectives.Stem cell reviews and reports · 2026Review
- The Nerve-Induced Adipose Stem Cells Promote Nerve Repair in Stress Urinary Incontinence by Regulating Schwann Cell Repair Phenotype Conversion Through Activation of the Notch Pathway.Molecular neurobiology · 2025Article
- Human dental pulp stem cells for spinal cord injury.Stem cell research & therapy · 2025Review
- Cell Therapy in the Treatment of Female Stress Urinary Incontinence: Current Status and Future Proposals.Life (Basel, Switzerland) · 2024Review
- Dental Pulp Stem Cells Modulate Inflammasome Pathway and Collagen Deposition of Dermal Fibroblasts.Cells · 2024Article
- Composite dietary antioxidant index in relation to urge urinary incontinence in US men.Frontiers in nutrition · 2024Article
- Animal models, treatment options, and biomaterials for female stress urinary incontinence.Frontiers in bioengineering and biotechnology · 2024Review
- Association between oxidative balance score and urinary incontinence in females: results from the national health and nutrition examination survey in 2005-2018.International urology and nephrology · 2023Article
- Notch and Wnt Signaling Modulation to Enhance DPSC Stemness and Therapeutic Potential.International journal of molecular sciences · 2023Review
- Flow-dependent shear stress affects the biological properties of pericyte-like cells isolated from human dental pulp.Stem cell research & therapy · 2023Article
- Preliminary study on mesenchymal stem cells in repairing nerve injury in pelvic floor denervation.Frontiers in bioengineering and biotechnology · 2023Article
- Human dental pulp stem cells (hDPSCs) promote the lipofibroblast transition in the early stage of a fibro-inflammatory process.Frontiers in cell and developmental biology · 2023Article
- Effect of Biodentine on Odonto/Osteogenic Differentiation of Human Dental Pulp Stem Cells.Bioengineering (Basel, Switzerland) · 2022Article
- Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications.World journal of stem cells · 2022Review
- Article
- Cell Technologies in the Stress Urinary Incontinence Correction.Biomedicines · 2022Review
- PEDOT: PSS promotes neurogenic commitment of neural crest-derived stem cells.Frontiers in physiology · 2022Article
- The potential roles of dental pulp stem cells in peripheral nerve regeneration.Frontiers in neurology · 2022Review
- Perinatal mesenchymal stromal cells of the human decidua restore continence in rats with stress urinary incontinence induced by simulated birth trauma and regulate senescence of fibroblasts from women with stress urinary incontinence.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the regenerative potential of human dental pulp stem cells (hDPSCs) in an animal model of stress urinary incontinence (SUI). SUI, an involuntary leakage of urine, is due to physical stress involving an increase in bladder pressure and a damage of external urethral sphincter affecting muscles and nerves. Conventional therapies can only relieve the symptoms. Human DPSCs are characterized by peculiar stemness and immunomodulatory properties and might provide an alternative tool for SUI therapy. MATERIALS AND
methodsIn vitro phase: hDPSCs were induced towards the myogenic commitment following a 24 hours pre-conditioning with 5-aza-2'-deoxycytidine (5-Aza), then differentiation was evaluated. In vivo phase: pudendal nerve was transected in female rats to induce stress urinary incontinence; then, pre-differentiated hDPSCs were injected in the striated urethral sphincter. Four weeks later, urethral sphincter regeneration was assayed through histological, functional and immunohistochemical analyses.
resultsHuman DPSCs were able to commit towards myogenic lineage in vitro and, four weeks after cell injection, hDPSCs engrafted in the external urethral sphincter whose thickness was almost recovered, committed towards myogenic lineage in vivo, promoted vascularization and an appreciable recovery of the continence. Moreover, hDPSCs were detected within the nerve, suggesting their participation in repair of transected nerve.
conclusionsThese promising data and further investigations on immunomodulatory abilities of hDPSCs would allow to make them a potential tool for alternative therapies of SUI.
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Registered trials
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