Evidence map›Paper›PMID 31552909›Full record

ArticleNeural regeneration research2020

Endothelin increases the proliferation of rat olfactory mucosa cells.

Bertrand Bryche, Audrey Saint-Albin, Claire Le Poupon Schlegel, Christine Baly, Patrice Congar, Nicolas Meunier

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bertrand BrycheNeurobiologie de l'olfaction, Institut National de Recherche Agronomique (INRA), Université Paris-Saclay, Jouy-en-Josas; Université de Versailles Saint-Quentin en Yvelines, Département de Biologie, Versailles, France.
Audrey Saint-AlbinNeurobiologie de l'olfaction, Institut National de Recherche Agronomique (INRA), Université Paris-Saclay, Jouy-en-Josas, France.
Claire Le Poupon SchlegelNeurobiologie de l'olfaction, Institut National de Recherche Agronomique (INRA), Université Paris-Saclay, Jouy-en-Josas, France.
Christine BalyNeurobiologie de l'olfaction, Institut National de Recherche Agronomique (INRA), Université Paris-Saclay, Jouy-en-Josas, France.
Patrice CongarNeurobiologie de l'olfaction, Institut National de Recherche Agronomique (INRA), Université Paris-Saclay, Jouy-en-Josas, France.
Nicolas MeunierNeurobiologie de l'olfaction, Institut National de Recherche Agronomique (INRA), Université Paris-Saclay, Jouy-en-Josas; Université de Versailles Saint-Quentin en Yvelines, Département de Biologie, Versailles, France.
Neurobiologie de l'Olfaction et Modélisation en Imagerie · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life. Among several factors regulating this renewal, endothelin acts as an anti-apoptotic factor in the rat olfactory epithelium. In the present study, we explored whether endothelin could also act as a proliferative factor. Using primary culture of the olfactory mucosa, we found that an early treatment with endothelin increased its growth. Consistently, a treatment with a mixture of BQ

Indexed as

autocrine factorcell culturecellular dynamicsendothelinolfactionolfactory basal cellsolfactory epitheliumolfactory mucosa primary culture

Identifiers

PMID31552909
PMCPMC6905347
OpenAlexW2975618070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.