Evidence map›Paper›PMID 31552740›Full record

ArticleNano letters2019

Engineering a Genetically Encoded Magnetic Protein Crystal.

Thomas L Li, Zegao Wang, He You, Qunxiang Ong, Vamsi J Varanasi, Mingdong Dong, Bai Lu, Sergiu P Paşca, Bianxiao Cui

Abstract read
In one paragraph

Article in Nano letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Chemical reviews · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Nanotechnology Enables Novel Modalities for Neuromodulation.Advanced materials (Deerfield Beach, Fla.) · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas L LiDepartment of Chemistry , Stanford University , Stanford , California 94305 , United States.ORCID 0000-0002-8656-0679
Zegao WangInterdisciplinary Nanoscience Center , Aarhus University , Aarhus 8000 , Denmark.
He YouSchool of Pharmaceutical Sciences , Tsinghua University , Beijing 100084 , China.
Qunxiang OngDepartment of Chemistry , Stanford University , Stanford , California 94305 , United States.
Vamsi J VaranasiDepartment of Chemistry , Stanford University , Stanford , California 94305 , United States.
Mingdong DongInterdisciplinary Nanoscience Center , Aarhus University , Aarhus 8000 , Denmark.ORCID 0000-0002-2025-2171
Bai LuSchool of Pharmaceutical Sciences , Tsinghua University , Beijing 100084 , China.
Sergiu P PaşcaDepartment of Psychiatry and Behavioral Sciences , Stanford University , Stanford , California 94305 , United States.
Bianxiao CuiDepartment of Chemistry , Stanford University , Stanford , California 94305 , United States.ORCID 0000-0002-8044-5629

Funding

Developing nanoscale electrophysiology sensors for robust intracellular recordingR01GM125737 · NIGMS · STANFORD UNIVERSITY · PI CUI, BIANXIAO · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM125737
6 · The paper itself

Abstract

Magnetogenetics is a new field that leverages genetically encoded proteins and protein assemblies that are sensitive to magnetic fields to study and manipulate cell behavior. Theoretical studies show that many proposed magnetogenetic proteins do not contain enough iron to generate substantial magnetic forces. Here, we have engineered a genetically encoded ferritin-containing protein crystal that grows inside mammalian cells. Each of these crystals contains more than 10 million ferritin subunits and is capable of mineralizing substantial amounts of iron. When isolated from cells and loaded with iron

Indexed as

AnimalsCrystallizationFerritinsHEK293 CellsHumansIronMagnetic FieldsMagnetsMiceProtein EngineeringRAW 264.7 CellsFerritinsIronferritinmagneticMagnetogeneticsprotein crystal

Identifiers

PMID31552740
PMCPMC7265822

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.