ArticleAllergy, asthma & immunology research2019
Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity.
Article in Allergy, asthma & immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02591550 (A Study on the Mechanism of Cough Hypersensitivity), which is not on this map. Cited by 39 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study on the Mechanism of Cough Hypersensitivity
Who cites it
39 citing papers in PubMed, 52 citations in OpenAlex.
- Observational
- Integrative genomics reveal genetic links of chronic cough with risk factors and brain regional volumes.ERJ open research · 2026Article
- Differences in Causes, Severity, and Treatment Outcomes Between Women and Men with Chronic Cough.Advances in respiratory medicine · 2026Article
- Investigation of the active compounds and pharmacological mechanisms ofFrontiers in medicine · 2026Article
- Association of the high-density lipoprotein cholesterol to C-reactive protein ratio with chronic cough in US adults: Effect modification by smoking status.Tobacco induced diseases · 2026Article
- Prevalence of cough and associated symptoms among pilgrims in large mass gathering event 2024: a cross-sectional study.IJID regions · 2025Article
- Establishment and validation of a cough prediction model for lung cancer survivors after pulmonary resection based on a systematic review and meta-analysis of 23 cohort studies.Journal of thoracic disease · 2025Article
- Prevalence and burden of chronic cough in China: results from a population-based survey.BMC pulmonary medicine · 2025Article
- Cough-Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology.The journal of allergy and clinical immunology. In practice · 2025Review
- Article
- Sex Differences in Chronic Cough Epidemiology: The Korean Cough Study Group.Journal of Korean medical science · 2024Article
- Profiles of Cough and Associated Risk Factors in Nonhospitalized Individuals With SARS-CoV-2 Omicron Variant Infection: Cross-Sectional Online Survey in China.JMIR public health and surveillance · 2024Article
- Gender Differences in Antitussive Prescriptions for Chronic Cough in Korea.Journal of clinical medicine · 2023Article
- New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study.Allergy, asthma & immunology research · 2023Article
- Cough Characteristics and Their Association Patterns According to Cough Etiology: A Network Analysis.Journal of clinical medicine · 2023Article
- Article
- Article
- Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China.Respiratory research · 2022Article
- A multicenter survey on the current status of chronic cough and its impact on quality of life in Guangdong, China.Journal of thoracic disease · 2022Article
- The risk factors for urinary incontinence in female adults with chronic cough.BMC pulmonary medicine · 2022Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeAn older female predominance has been reported among chronic cough patients in Western countries, which is considered to be associated with a higher cough sensitivity in females. However, the characteristics of Chinese chronic cough patients remain unclear. This study aimed to explore the age and sex distribution as well as their relationship with cough reflex sensitivity to capsaicin in Chinese chronic cough patients.
methodsWe analyzed the demographic features of 1,882 consecutive chronic cough patients who attended our cough clinic in Guangzhou, China. Cough sensitivity to capsaicin, which was defined as the lowest concentration of capsaicin causing 5 coughs or more (C5), was measured in 539 of the 1,882 patients and 68 healthy volunteers.
resultsThe mean age of the patients was 43.0 ± 13.7 years and patients aged <50 years accounted for more than two-thirds of the study population. Around 87% of the patients were never-smokers. The proportion of females (51.5%) was almost equal to that of males (48.5%). The pattern of the age and sex distribution was consistently reflected within most common causes of chronic cough, while a female predominance was shown in patients with cough-variant asthma and patients aged ≥50 years. Female patients had higher cough sensitivity to capsaicin than male patients (log C5: 1.58 ± 0.84 vs. 2.04 ± 0.84 μmol/L,
conclusionsIn China, patients with chronic cough have a roughly equal sex distribution and a middle-aged predominance, irrespective of a higher cough sensitivity to capsaicin in females and older patients.
trial registrationClinicalTrials.gov Identifier: NCT02591550.
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Registered trials
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