ArticleJournal of neuro-oncology2019
Risk factors for intraoperative stimulation-related seizures during awake surgery: an analysis of 109 consecutive patients.
Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Feasibility of perampanel monotherapy for seizure management during awake craniotomy for glioma.Journal of neuro-oncology · 2026Article
- Feasibility and safety of awake craniotomy in adult patients with drug-resistant focal epilepsy.Epilepsia · 2025Observational
- Comparative analysis of monotherapy versus duotherapy with antiseizure medications for intraoperative and early postoperative seizure control in glioma patients undergoing awake craniotomy.Journal of neuro-oncology · 2025Article
- Article
- Risk factors and predictors of intraoperative seizures during awake craniotomy: A systematic review and meta-analysis.Surgical neurology international · 2023Review
- Focal Cortical Surface Cooling is a Novel and Safe Method for Intraoperative Functional Brain Mapping.World neurosurgery · 2021Article
- Preoperative Prediction of Communication Difficulties during Awake Craniotomy in Glioma Patients: A Retrospective Evaluation of 136 Cases at a Single Institution.Neurologia medico-chirurgica · 2021Article
- Letter to the Editor: Awake Craniotomy for Intracranial Gliomas During Coronavirus Disease 2019 Pandemic.World neurosurgery · 2020Article
- Anesthetic considerations for awake craniotomy.Anesthesia and pain medicine · 2020Review
- Targeting the medulloblastoma: a molecular-based approach.Acta bio-medica : Atenei Parmensis · 2020Review
- Potential roads for reaching the summit: an overview on target therapies for high-grade gliomas.Acta bio-medica : Atenei Parmensis · 2020Review
- Minimal Invasive Piezoelectric Osteotomy in Neurosurgery: Technic, Applications, and Clinical Outcomes of a Retrospective Case Series.Veterinary sciences · 2020Article
- Trauma Coagulopathy and Its Outcomes.Medicina (Kaunas, Lithuania) · 2020Observational
- Review
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDuring surgery for lesions in eloquent areas the goal is to achieve the widest resection possible, without loss of neurological function. Intraoperative seizures may lead to abandonment of the procedure or damages to the patient. Awareness regarding the predictors of IOS would help the surgeon. The aim of this retrospective study was to identify the factors associated with the occurrence of IOS in patients who underwent awake surgery for removal of gliomas in eloquent areas.
methodsThis was a retrospective analysis of prospectively collected data of 109 patients who underwent awake craniotomy between January 2010 and December 2017 for removal of gliomas. IOS were defined as tonic-clonic seizures or loss of consciousness resulting in communication difficulties with the patient occurring during cortical and subcortical mapping.
resultsA total of 109 patients were included in this study and IOS occurred in 9 (8.2%) patients. Demographic and clinical factors were comparable between patients with and without IOS. In the IOS group, 7 (77.8%) patients had seizures preoperatively and 4 (57.1%) were on more than one perioperative antiepileptic drugs (AED).
conclusionsThe current series add some hints to the poorly studied IOS risk during awake surgery. The risk of IOS appears to be relatively higher in patients with anteriorly located tumors and in patients operated without intraoperative brain activity monitoring and different patterns of stimulation for language and sensory-motor mapping. Further studies are needed to clarify the role of intraoperative techniques.
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