Observational studyJournal of neuro-oncology2019
Cognitive functioning and predictors thereof in patients with 1-10 brain metastases selected for stereotactic radiosurgery.
Observational study in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02953756 (Cognitive Outcome After Gamma Knife Radiosurgery in Patients With 1-10 Brain Metastases), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognitive Outcome After Gamma Knife Radiosurgery in Patients With 1-10 Brain Metastases
Who cites it
13 citing papers in PubMed.
- The long-term course and relationship with survival of multidimensional fatigue in patients with brain metastases after Gamma Knife radiosurgery.Journal of cancer research and clinical oncology · 2023Trial
- The impact of financial toxicity on quality of life for survivors of primary brain tumour.Journal of cancer survivorship : research and practice · 2025Article
- Neuropsychological Evaluation for Oncology.Neurologic clinics · 2024Review
- Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study.Neuro-oncology practice · 2024Article
- Presurgical Executive Functioning in Low-Grade Glioma Patients Cannot Be Topographically Mapped.Cancers · 2023Article
- Review
- Review
- Factors associated with cognitive impairment and cognitive concerns in patients with metastatic non-small cell lung cancer.Neuro-oncology practice · 2022Article
- Whole Brain Irradiation or Stereotactic RadioSurgery for five or more brain metastases (WHOBI-STER): A prospective comparative study of neurocognitive outcomes, level of autonomy in daily activities and quality of life.Clinical and translational radiation oncology · 2022Article
- Review of Conventional and High Dose Rate Brain Radiation (FLASH): Neurobehavioural, Neurocognitive and Assessment Issues in Rodent Models.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2021Review
- Health-related quality of life after Gamma Knife radiosurgery in patients with 1-10 brain metastases.Journal of cancer research and clinical oncology · 2021Observational
- Late effects of cancer treatment: consequences for long-term brain cancer survivors.Neuro-oncology practice · 2021Review
- Neurological outcome and memory performance in patients with 10 or more brain metastases treated with frameless linear accelerator (LINAC)-based stereotactic radiosurgery.Journal of neuro-oncology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeInformation on predictive factors of cognitive functioning in patients with (multiple) brain metastases (BM) selected for radiosurgery may allow for more individual care and may play a role in predicting cognitive outcome after radiosurgery. The aim of this study was to evaluate cognitive performance, and predictors thereof, in patients with 1-10 BM before radiosurgery.
methodsCognition was measured before radiosurgery using a standardized neuropsychological test battery in patients with 1-10 BM (expected survival > 3 months; KPS ≥ 70; no prior BM treatment). Regression formulae were constructed to calculate sociodemographically corrected z scores. Group and individual cognitive functioning was analyzed. Multivariable regression was used to explore potential predictors.
resultsPatients (N = 92) performed significantly worse than controls (N = 104) on all 11 test variables (medium-large effect sizes for 8 variables). Percentages of impairment were highest for information processing (55.3%), dexterity (43.2%) and cognitive flexibility (28.7%). 62% and 46% of patients had impairments in at least two, or three test variables, respectively. Models including combinations of clinical and psychological variables were predictive of verbal memory, psychomotor speed, information processing and dexterity. Neither number nor volume of metastases predicted patients' test performance.
conclusionsAlready before radiosurgery, almost half of the patients suffered from severe cognitive deficits in at least three test variables. At group and individual level, information processing, cognitive flexibility, and dexterity were most affected. These cognitive impairments may impair daily functioning and patients' ability to make (shared) treatment decisions. Both clinical (symptomatic BM; timing of BM diagnosis) and psychological (mental fatigue) characteristics influenced cognitive performance. CLINICAL TRIAL INFORMATION: Cognition and Radiation Study A (CAR-Study A; ClinicalTrials.gov Identifier: NCT02953756; Medical Ethics Committee file number: NL53472.028.15/P1515).
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