Evidence map›Paper›PMID 31552584›Full record

Trial reportEndocrine2020

Prednisolone or hydrocortisone replacement in patients with corticotrope deficiency fasting during Ramadan result in similar risks of complications and quality of life: a randomized double-blind controlled trial.

Melika Chihaoui, Wafa Mimita, Ibtissem Oueslati, Ons Rejeb, Zohra Ben Amor, Wafa Grira, Meriem Yazidi, Fatma Chaker

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05827965 nacompletednot on this mapstarted 2023, after this paper: background citation

Ramadan Fasting in Secondary Adrenal Insufficiency Patients

TypeinterventionalSponsorHopital La RabtaRan2023 to 2024Enrolled63ConditionsSecondary Adrenal Insufficiency, Fasting, IntermittentArmseducation and drug adjustement
NCT07367425 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone.

TypeinterventionalSponsorHopital La RabtaRan2026 to 2026Enrolled35ConditionsPrimary Adrenal Insufficiency, Ramadan Fasting, Prednisolone, Continuous Glucose MonitoringArmsRamadan fasting
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Melika ChihaouiDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia. melikachihaoui@yahoo.fr.ORCID 0000-0001-7991-9885
Wafa MimitaDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Ibtissem OueslatiDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Ons RejebDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Zohra Ben AmorDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Wafa GriraDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Meriem YazidiDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Fatma ChakerDepartment of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Tunis University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aims of the study were to compare the risk of complications and the quality of life in patients with corticotrope deficiency, who fasted during Ramadan. Both hydrocortisone and prednisolone were compared as treatments.

methodsA randomized double-blind crossover clinical trial conducted in the department of Endocrinology of the University Hospital la Rabta in Tunis, during Ramadan 2018, on 53 patients with known corticotrope deficiency treated with hydrocortisone 20 mg per day and who were willing to fast during Ramadan. Patients were randomized into two groups; AB that received hydrocortisone twice daily for 14 days then prednisolone once daily with a placebo for 14 days and group BA that received the two treatments in the reverse order. Patients had to complete a daily follow-up sheet about their eating and sleeping habits, the occurrence of complications and blood glucose monitoring and also to respond to the AddiQoL questionnaire at the end of each treatment period.

resultsFifty patients' data were analyzed; 29 men, mean age: 42.4 ± 13.3 years, mean duration of the disease: 8.1 ± 7.6 years. The frequency of complications, mean blood glucose levels and the quality of life did not differ on hydrocortisone compared to prednisolone after adjustment for the sequence of the treatment.

conclusionsthe risks of Ramadan fasting in patients with corticotrope deficiency were the same on hydrocortisone or prednisolone.

Indexed as

HydrocortisoneQuality of LifeAdultBlood GlucoseBlood Glucose Self-MonitoringFastingHumansIslamMaleMiddle AgedPrednisoloneBlood GlucoseHydrocortisonePrednisoloneAdrenal insufficiencyClinical trialDouble blindFastingHormone replacement therapyHypoglycemiaQuality of lifeRandomized

Identifiers

PMID31552584
OpenAlexW2975715569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.