Evidence map›Paper›PMID 31552493›Full record

ArticlePediatric surgery international2019

Therapeutic potential of spheroids of stem cells from human exfoliated deciduous teeth for chronic liver fibrosis and hemophilia A.

Yoshiaki Takahashi, Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Haruyoshi Yamaza, Kosuke Kirino, Koichiro Yoshimaru, Toshiharu Matsuura, Tomoaki Taguchi

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Article in Pediatric surgery international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yoshiaki TakahashiDepartment of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Ratih YuniarthaDepartment of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Takayoshi YamazaDivision of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. yamazata@dent.kyushu-u.ac.jp.
Soichiro SonodaDivision of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Haruyoshi YamazaDepartment of Pediatric Dentistry, Division of Oral Health, Growth, and Development, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan.
Kosuke KirinoDepartment of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Koichiro YoshimaruDepartment of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Toshiharu MatsuuraDepartment of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Tomoaki TaguchiDepartment of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Kyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMesenchymal stem cell (MSC)-based cell therapies have emerged as a promising treatment option for various diseases. Due to the superior survival and higher differentiation efficiency, three-dimensional spheroid culture systems have been an important topic of MSC research. Stem cells from human exfoliated deciduous teeth (SHED) have been considered an ideal source of MSCs for regenerative medicine. Thus, in the present study, we introduce our newly developed method for fabricating SHED-based micro-hepatic tissues, and demonstrate the therapeutic effects of SHED-based micro-hepatic tissues in mouse disease models.

methodsSHED-converted hepatocyte-like cells (SHED-HLCs) were used for fabricating spherical micro-hepatic tissues. The SHED-HLC-based spheroids were then transplanted both into the liver of mice with CCl

resultsIntrahepatic transplantation of SHED-HLC-spheroids improved the liver dysfunction in association with anti-fibrosis effects in CCl

conclusionsThese findings suggest that SHED-HLC-based micro-hepatic tissues might be a promising source for treating pediatric refractory diseases, including chronic liver fibrosis and hemophilia A.

Indexed as

Mesenchymal Stem Cell TransplantationTooth, DeciduousTransplantation, HeterologousAnimalsCell DifferentiationChildChild, PreschoolChronic DiseaseDisease Models, AnimalHemophilia AHepatocytesHumansLiver CirrhosisMaleMesenchymal Stem CellsMiceChronic liver fibrosisHemophilia ASHEDSpheroidsTransplantation

Identifiers

PMID31552493
OpenAlexW2976431874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.