ArticleClinical neuroradiology2020
The Chalice Sign : Characteristic Morphology of the Cervical Carotid Bifurcation in Patients with Loeys-Dietz Syndrome.
Article in Clinical neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Association between cervicocerebral artery dissection and tortuosity - a review on quantitative and qualitative assessment.Acta neurochirurgica · 2024Review
- Echogenomics: Echocardiography in Heritable Aortopathies.Current cardiology reports · 2024Review
- Loeys-Dietz syndrome: Case report and review of the literature.Radiology case reports · 2022Article
- Toward precision medicine in vascular connective tissue disorders.American journal of medical genetics. Part A · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeLoeys-Dietz syndrome (LDS) is a connective tissue disorder characterized by arterial aneurysms and dissections. This study sought to assess and describe the arterial changes of the cervical arterial vasculature of such patients, with an emphasis on the carotid bifurcation. MATERIAL AND
methodsA retrospective review of patients with a known diagnosis of LDS was carried out. The maximum diameters of the external carotid artery (ECA) and internal carotid artery (ICA) origins, common carotid artery (CCA) terminus, maximum transverse and craniocaudal dimensions of the carotid bulb, and bifurcation angle were measured. The presence of a chalice sign was defined as a carotid bifurcation angle of ≥80°. A semi-quantified analysis of vertebral artery tortuosity was completed as well. All measurements were compared to a cohort of age-matched controls.
resultsA total of 21 patients with LDS were included. Compared to normal controls, the presence of a chalice sign had 61.9% sensitivity and 100.0% specificity for LDS if present bilaterally; the sensitivity and specificity of a unilateral chalice sign were 66.7% and 82.3%, respectively. Patients with LDS also had significantly higher rates of a bilateral chalice sign compared to patients with vascular Ehlers-Danlos syndrome (vEDS) (61.9% versus 0%, P <0.0001) and patients with Marfan syndrome (61.9% versus 14.3%, P = 0.001).
conclusionPatients with LDS have characteristic findings of the cervical arterial vasculature that enables them to be distinguished from normal controls as well as patients with connective tissue diseases, such as Marfan syndrome and vEDS; most notably including marked widening of the carotid bifurcation angle in what is proposed to be named the chalice sign.
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