Evidence map›Paper›PMID 31552412›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome.

Sara C Auld, Pholo Maenetje, Shruthi Ravimohan, Drew Weissman, Itai Ncube, Mandla Mlotshwa, Nelly Ratsela, William Chase, Mboyo-Di-Tamba Vangu, Robert Wallis and 3 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Observational
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sara C AuldSchool of Medicine and Rollins School of Public Health, Emory University, Atlanta, Georgia.
Pholo MaenetjeAurum Institute, Johannesburg, South Africa.
Shruthi RavimohanDepartment of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Drew WeissmanDepartment of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Itai NcubeAurum Institute, Johannesburg, South Africa.
Mandla MlotshwaAurum Institute, Johannesburg, South Africa.
Nelly RatselaAurum Institute, Johannesburg, South Africa.
William ChaseDepartment of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Mboyo-Di-Tamba VanguNuclear Medicine, CM Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
Robert WallisAurum Institute, Johannesburg, South Africa.
Gavin ChurchyardAurum Institute, Johannesburg, South Africa.
Hardy KornfeldDepartment of Medicine, University of Massachusetts Medical School, Worcester.
Gregory P BissonDepartment of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
Rapid Immune Restoration and Lung Injury in HIV/TBR01AI120821 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BISSON, GREGORY P. · 2015 to 2019
$3.3M
Impact of HIV infection on early responses to TB exposureK23AI134182 · NIAID · EMORY UNIVERSITY · PI AULD, SARA · 2018 to 2023
$972k
NCATS NIH HHS KL2 TR001879NIAID NIH HHS K23 AI134182NIAID NIH HHS P30 AI045008NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI120821
6 · The paper itself

Abstract

End-organ impairment has received relatively little research attention as a possible manifestation of tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS). In this prospective cohort study, one-half of adults with human immunodeficiency virus and pulmonary tuberculosis experienced meaningful declines in lung function on antiretroviral therapy, suggesting a role for lung function in TB-IRIS definitions.

Indexed as

HIV InfectionsImmune Reconstitution Inflammatory SyndromeTuberculosisAdultHIVHumansLungProspective StudiesHIVimmune reconstitution inflammatory syndromepulmonary functiontuberculosis

Identifiers

PMID31552412
PMCPMC7146005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.