ReviewGeneral psychiatry2019
Placebo effects and the molecular biological components involved.
Review in General psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sham treatment effects in manual therapy trials on back pain patients: a systematic review and pairwise meta-analysis.BMJ open · 2021Pooled it
- Article
- Prospective study to evaluate the effectiveness of guideline-based therapy for chronic cough and refractory chronic cough: PROCOUGH.ERJ open research · 2026Article
- "The Dark Side of Musculoskeletal Care": Why Do Ineffective Techniques Seem to Work? A Comprehensive Review of Complementary and Alternative Therapies.Biomedicines · 2025Review
- Decoding the impact of the placebo response in clinical trials for chronic cough.ERJ open research · 2024Article
- SAS macro programme for Bang's Blinding Index to assess and visualise the success of blinding in randomised controlled trials.General psychiatry · 2024Review
- A novel transcranial photobiomodulation device to address motor signs of Parkinson's disease: a parallel randomised feasibility study.EClinicalMedicine · 2023Article
- The Biology of Placebo and Nocebo Effects on Experimental and Chronic Pain: State of the Art.Journal of clinical medicine · 2023Review
- Placebo stimulates neuroplasticity in depression: implications for clinical practice and research.Frontiers in psychiatry · 2023Article
- Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.General psychiatry · 2022Article
- Inflammation and immunity connect hypertension with adverse COVID-19 outcomes.Frontiers in genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmacologically inactive substances have been used in medicine for more than 700 years and can trigger beneficial responses in the human body, which is referred to as the placebo effects or placebo responses. This effect is robust enough to influence psychosocial and physiological responses to the placebo and to active treatments in many settings, which has led to increased interest from researchers. In this article, we summarise the history of placebo, the characteristics of placebo effects and recent advancements reported from the studies on placebo effects and highlight placebome studies to identify various molecular biological components associated with placebo effects. Although placebos have a long history, the placebome concept is still in its infancy. Although behavioural, neurobiological and genetic studies have identified that molecules in the dopamine, opioid, serotonin and endocannabinoid systems might be targets of the placebo effect, placebome studies with a no-treatment control (NTC) are necessary to identify whole-genome genetic targets. Although bioinformatics analysis has identified the molecular placebome module, placebome studies with NTCs are also required to validate the related findings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.