ReviewFrontiers in cell and developmental biology2019
The Role of the Optical Stretcher Is Crucial in the Investigation of Cell Mechanics Regulating Cell Adhesion and Motility.
Review in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Comparative mechanical profiling of MCF-7 cells in 2D and 3D cultures via optical tweezers.Biomedical optics express · 2026Article
- Looking at endometriosis-diagnosis and disease mechanisms through a mechanical lens.Frontiers in medicine · 2026Review
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- Organoids meet microfluidics: recent advancements, challenges, and future of organoids-on-chip.In vitro models · 2025Review
- Advanced Mechanical Testing Technologies at the Cellular Level: The Mechanisms and Application in Tissue Engineering.Polymers · 2023Review
- Methods to mechanically perturb and characterize GUV-based minimal cell models.Computational and structural biotechnology journal · 2023Review
- Review
- mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells.Cancers · 2022Article
- Automated estimation of cancer cell deformability with machine learning and acoustic trapping.Scientific reports · 2022Article
- Switching in the expression pattern of actin isoforms marks the onset of contractility and distinct mechanodynamic behavior during cardiomyocyte differentiation.Physiological reports · 2022Article
- PINCH1 Promotes Fibroblast Migration in Extracellular Matrices and Influences Their Mechanophenotype.Frontiers in cell and developmental biology · 2022Article
- A survey of physical methods for studying nuclear mechanics and mechanobiology.APL bioengineering · 2021Review
- The Mechanical Fingerprint of Circulating Tumor Cells (CTCs) in Breast Cancer Patients.Cancers · 2021Article
- The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration.Frontiers in cell and developmental biology · 2021Article
- Effect of Nuclear Stiffness on Cell Mechanics and Migration of Human Breast Cancer Cells.Frontiers in cell and developmental biology · 2020Article
- Inhomogeneities in 3D Collagen Matrices Impact Matrix Mechanics and Cancer Cell Migration.Frontiers in cell and developmental biology · 2020Article
- Mechanical Cues Affect Migration and Invasion of Cells From Three Different Directions.Frontiers in cell and developmental biology · 2020Review
- Effect of PAK Inhibition on Cell Mechanics Depends on Rac1.Frontiers in cell and developmental biology · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanical properties of cells, tissues, and the surrounding extracellular matrix environment play important roles in the process of cell adhesion and migration. In physiological and pathological processes of the cells, such as wound healing and cancer, the capacity to migrate through the extracellular matrix is crucial. Hence biophysical techniques were used to determine the mechanical properties of cells that facilitate the various migratory capacities. Since the field of mechanobiology is rapidly growing, the reliable and reproducible characterization of cell mechanics is required that facilitates the adhesion and migration of cells. One of these cell mechanical techniques is the optical stretching device, which was originally developed to investigate the mechanical properties of cells, such as the deformation of single cells in suspension. After discussing the strengths and weaknesses of the technology, the latest findings in optical stretching-based cell mechanics are presented in this review. Finally, the mechanical properties of cells are correlated with their migratory potential and it is pointed out how the inhibition of biomolecules that contribute to the to the maintenance of cytoskeletal structures in cells affect their mechanical deformability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.