Evidence map›Paper›PMID 31552197›Full record

ArticleFrontiers in cellular and infection microbiology2019

Effects of the PA-X and PB1-F2 Proteins on the Virulence of the 2009 Pandemic H1N1 Influenza A Virus in Mice.

Jun Ma, Shun Li, Kangjian Li, Xiangbin Wang, Shoujun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Update on the Efficacy of Vaccination on Host Immunity to Influenza Virus Infection.International archives of allergy and immunology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Roles of Ubiquitination in Pathogenesis of Influenza Virus Infection.International journal of molecular sciences · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jun MaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Shun LiSchool of Life Science and Engineering, Foshan University, Foshan, China.
Kangjian LiSchool of Life Science and Engineering, Foshan University, Foshan, China.
Xiangbin WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Shoujun LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
South China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been several previous reports showing that PA-X and PB1-F2 proteins can regulate innate immune responses and may play roles in the adaptation of influenza viruses to new hosts. In this research, we investigated, for the first time, the combined effects of PA-X and PB1-F2 proteins on viral virulence in mice. Based on the 2009 pH1N1 A/Guangdong/1057/2010 virus backbone, four viruses encoding different combinations of full-length or truncated PA-X and PB1-F2 proteins were rescued by a reverse genetic engineering system. We analyzed viral replication, host-shutoff activity,

Indexed as

AnimalsDisease Models, AnimalImmunity, InnateInfluenza A Virus, H1N1 SubtypeMiceOrthomyxoviridae InfectionsRepressor ProteinsReverse GeneticsViral Nonstructural ProteinsViral ProteinsVirulenceVirulence FactorsVirus ReplicationPA-X protein, influenza A virusPB1-F2 protein, Influenza A virusRepressor ProteinsViral Nonstructural ProteinsViral ProteinsVirulence Factorshost-shutoffinfluenzamicePA-XPB1-F2

Identifiers

PMID31552197
PMCPMC6734165
OpenAlexW2969436274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.