Evidence map›Paper›PMID 31552058›Full record

ArticleFrontiers in immunology2019

The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils.

Christophe Pellefigues, Palak Mehta, Melanie Sarah Prout, Karmella Naidoo, Bibek Yumnam, Jodie Chandler, Sally Chappell, Kara Filbey, Mali Camberis, Graham Le Gros

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  6. Article
  7. Review
  8. Elastase- and LPS-Exposed Cpa3Frontiers in immunology · 2022
    Article
  9. Basophils from allergy to cancer.Frontiers in immunology · 2022
    Review
  10. Article
  11. Basophils promote barrier dysfunction and resolution in the atopic skin.The Journal of allergy and clinical immunology · 2021
    Article
  12. Diverse innate stimuli activate basophils through pathways involving Syk and IκB kinases.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Is There a Role for Basophils in Cancer?Frontiers in immunology · 2020
    Review
  14. Review
  15. Immunobiology of Acquired Resistance to Ticks.Frontiers in immunology · 2020
    Review
  16. The Gastrointestinal HelminthFrontiers in immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Christophe PellefiguesThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Palak MehtaThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Melanie Sarah ProutThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Karmella NaidooThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Bibek YumnamThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Jodie ChandlerThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Sally ChappellThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Kara FilbeyThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Mali CamberisThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Graham Le GrosThe Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand.
Malaghan Institute of Medical Research · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has proven to be controversial due to their relative rarity and their complex lineage phenotype. Here, we show that the expression of basophils lineage markers CD200R3 and FcεRIα is highly variable in inflammatory settings and hinders basophils identification by flow cytometry across multiple disease states or tissues. Fluorophore-conjugated antibody staining of these lineage markers strongly activates basophil type 2 cytokine expression, and represents a potential bias for coculture or

Indexed as

AnimalsBasophilsHypersensitivityInflammationMice, Inbred C57BLSkinBasoph8basophildepletionflow cytometryphenotype

Identifiers

PMID31552058
PMCPMC6746837
OpenAlexW2970734644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.